Favorable modulation of benign breast tissue and serum risk biomarkers is associated with > 10 % weight loss in postmenopausal women.
Favorable modulation of benign breast tissue and serum risk biomarkers is associated with > 10 % weight loss in postmenopausal women.
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DOI：
10.1007/s10549-013-2730-8
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发表时间：
2013-11
影响因子：
3.8
通讯作者：
Hursting, Stephen D.
中科院分区：
文献类型：
--
作者：
Fabian, Carol J.;Kimler, Bruce F.;Donnelly, Joseph E.;Sullivan, Debra K.;Klemp, Jennifer R.;Petroff, Brian K.;Phillips, Teresa A.;Metheny, Trina;Aversman, Sonya;Yeh, Hung-wen;Zalles, Carola M.;Mills, Gordon B.;Hursting, Stephen D.
我们对绝经后超重和肥胖女性进行了一项为期6个月的行为减肥干预的II期可行性研究，这些女性患乳腺癌的风险增加，减肥对拟人、血液和良性乳腺组织生物标志物的影响。67名妇女采用随机乳晕周围细针抽吸（RPFNA）筛查，27名登记，24名参加介入期。24名可评估生物标志物的女性的基线BMI中位数为34.2 kg/m2，平均体重减轻了初始体重的11%。干预6个月后，Ki-67（如果限于基线时Ki-67的15名妇女，p=0.041）、脂联素/瘦素比率（p=0.003）的组织生物标志物显著调节；细胞周期蛋白B1 （p=0.001）、视网膜母细胞瘤磷酸化蛋白（p=0.005）和核糖体S6蛋白（p=0.004）。对性激素结合球蛋白（p<0.001）、生物有效雌二醇（p<0.001）、生物有效睾酮（p=0.033）、胰岛素（p=0.018）、脂联素（p=0.001）、瘦素（p<0.001）、脂联素/瘦素比值（p<0.001）、c反应蛋白（p=0.002）和肝细胞生长因子（p=0.011）等血清标志物有良好的调节作用。当体重下降<或< 10%时，只有体重从基线下降< 10%的女性，全身和内脏脂肪百分比、体力活动以及大多数血清和组织生物标志物的变化才会得到显著调节。一些因子，如血清PAI-1和乳腺组织pS2（雌激素诱导基因）mRNA，总体上没有显著调节，但仅考虑体重减轻100 - 10%的人。综上所述，6个月内中位体重减轻11%对许多拟人化、乳腺组织和血清风险及机制标志物有有利的调节作用。体重减轻10%或更多应该是肥胖女性乳腺癌风险降低研究的目标。
We conducted a phase II feasibility study of a 6 month behavioral weight loss intervention in postmenopausal overweight and obese women at increased risk for breast cancer and the effects of weight loss on anthropomorphic, blood, and benign breast tissue biomarkers. 67 women were screened by random peri-areolar fine needle aspiration (RPFNA), 27 were registered and 24 participated in the interventional phase. The 24 biomarker evaluable women had a median baseline BMI of 34.2 kg/m2 and lost a median of 11% of their initial weight. Significant tissue biomarker modulation after the 6 month intervention was noted for Ki-67 (if restricted to the 15 women with any Ki-67 at baseline, p=0.041), adiponectin to leptin ratio (p=0.003); and cyclin B1 (p=0.001), phosphorylated retinoblastoma (p=0.005), and ribosomal S6 (p=0.004) proteins. Favorable modulation for serum markers was observed for sex hormone binding globulin (p<0.001), bioavailable estradiol (p<0.001), bioavailable testosterone (p=0.033), insulin (p=0.018), adiponectin (p=0.001), leptin (p<0.001), the adiponectin to leptin ratio (p<0.001), C-reactive protein (p=0.002) and hepatocyte growth factor (p=0.011). When subdivided by < or > 10% weight loss, change in percent total body and android (visceral) fat, physical activity and the majority of the serum and tissue biomarkers were significantly modulated only for women with >10% weight loss from baseline. Some factors such as serum PAI-1 and breast tissue pS2 (estrogen inducible gene) mRNA were not significantly modulated overall but were when considering only those with >10% weight loss. In conclusion, a median weight loss of 11% over 6 months resulted in favorable modulation of a number of anthropomorphic, breast tissue and serum risk and mechanistic markers. Weight loss of 10% or more should likely be the goal for breast cancer risk reduction studies in obese women.
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影响因子：
3.3
作者：
Fabian, Carol J.;Kimler, Bruce F.;Johnson, Karen A.
通讯作者：
Johnson, Karen A.
影响因子：
5.8
作者：
Hofseth, LJ;Raafat, AM;Haslam, SZ
通讯作者：
Haslam, SZ
影响因子：
11.2
作者：
Imayama I;Ulrich CM;Alfano CM;Wang C;Xiao L;Wener MH;Campbell KL;Duggan C;Foster-Schubert KE;Kong A;Mason CE;Wang CY;Blackburn GL;Bain CE;Thompson HJ;McTiernan A
通讯作者：
McTiernan A
影响因子：
3.8
作者：
Harvie, M;Howell, A;Sellers, TA
通讯作者：
Sellers, TA
影响因子：
3.8
作者：
Ibarra-Drendall, Catherine;Wilke, Lee G.;Seewaldt, Victoria L.
通讯作者：
Seewaldt, Victoria L.