Cancer risks among patients with type 2 diabetes: a 10-year follow-up study of a nationwide population-based cohort in Taiwan.
Cancer risks among patients with type 2 diabetes: a 10-year follow-up study of a nationwide population-based cohort in Taiwan.
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DOI：
10.1186/1471-2407-14-381
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发表时间：
2014-05-29
期刊：
影响因子：
3.8
通讯作者：
Li TC
中科院分区：
文献类型：
--
作者：
Lin CC;Chiang JH;Li CI;Liu CS;Lin WY;Hsieh TF;Li TC
本研究旨在通过对包括台湾糖尿病患者和台湾普通人群的全国人群队列进行随访研究，确定2型糖尿病患者的癌症风险，并使用标准化发病率比（SIR，95% CI）估计台湾人群中可归因于2型糖尿病的部位特异性癌症风险的人群归因分数（PAF）。2型糖尿病受试者包括472，979例年龄≥20岁的患者，而一般人群包括9，411，249例年龄相同但无糖尿病的个体。受试者从1997年至1998年确定，并随访至2007年12月31日或直至任何癌症的首次表现。与主要分析和敏感性分析一致的男性中风险增加的癌症部位包括胰腺（SIR = 1.62; 95% CI = 1.53 - 1.72），肝脏（1.61; 1.57至1.64）、肾脏（1.32; 1.25至1.40）、口服（1.16，1.12至1.21）和结肠直肠（1.19，1.15至1.22）。女性中风险增加的癌症部位包括肝脏（1.55; 1.51至1.60），胰腺（1.44; 1.34至1.55），肾脏（1.38; 1.30 - 1.46）、子宫内膜（1.36; 1.26 - 1.47）、膀胱（1.19; 1.11 - 1.27）、结肠直肠（1.16; 1.13 - 1.20）和乳腺（1.14; 1.09 - 1.18）。总体而言，男性（4.0%）和女性（3.7%）中肝癌的PAF最高，其次是男性胰腺癌（3.4%）和肾癌（1.6%），然后是女性子宫内膜癌（1.8%）和肾癌（1.8%）。我们的数据表明，癌症风险增加与2型糖尿病有关。
This study aims to determine cancer risks among patients with type 2 diabetes through a follow-up study on a nationwide population-based cohort that included Taiwanese diabetic patients and general population in Taiwan as well as to estimate the population attributable fraction (PAF) of site-specific cancer risks that can be attributed to type 2 diabetes in Taiwanese population by using standardized incidence ratios (SIRs, 95% CI). Subjects with type 2 diabetes consisted of 472,979 patients aged ≥20 years, whereas general population consisted of 9,411,249 individuals of the same age limit but are not diabetic. Subjects were identified from 1997 to 1998 and followed up until December 31, 2007 or until the first manifestation of any cancer. Cancer sites with increased risks in men, which were consistent with the main and sensitivity analyses, included pancreas (SIR = 1.62; 95% CI = 1.53 to 1.72), liver (1.61; 1.57 to 1.64), kidney (1.32; 1.25 to 1.40), oral (1.16, 1.12 to 1.21), and colorectal (1.19, 1.15 to 1.22). Cancer sites with increased risks in women included liver (1.55; 1.51 to 1.60), pancreas (1.44; 1.34 to 1.55), kidney (1.38; 1.30 to 1.46), endometrium (1.36; 1.26 to 1.47), bladder (1.19; 1.11 to 1.27), colorectal (1.16; 1.13 to 1.20), and breast (1.14; 1.09 to 1.18). Overall, PAFs were highest for liver cancer in men (4.0%) and women (3.7%), followed by pancreas (3.4%) and kidney (1.6%) cancers in men, and then for endometrium (1.8%) and kidney (1.8%) cancers in women. Our data suggested that increased cancer risks are associated with type 2 diabetes.
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影响因子：
4.5
作者：
Lin CC;Li CI;Hsiao CY;Liu CS;Yang SY;Lee CC;Li TC
通讯作者：
Li TC
DOI：
10.1634/theoncologist.2009-0300
发表时间：
2010
期刊：
The oncologist
影响因子：
--
作者：
Hemminki K;Li X;Sundquist J;Sundquist K
通讯作者：
Sundquist K
影响因子：
254.7
作者：
Giovannucci, Edward;Harlan, David M.;Yee, Douglas
通讯作者：
Yee, Douglas
影响因子：
16.2
作者：
Michels, KB;Solomon, CG;Manson, JE
通讯作者：
Manson, JE
影响因子：
6.9
作者：
Considine, Robert V.;Premkumar, Ahalya;Sumner, Anne E.
通讯作者：
Sumner, Anne E.