Risk of cancer following hospitalization for type 2 diabetes.
Risk of cancer following hospitalization for type 2 diabetes.
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DOI：
10.1634/theoncologist.2009-0300
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发表时间：
2010
期刊：
影响因子：
--
通讯作者：
Sundquist K
中科院分区：
文献类型：
--
作者：
Hemminki K;Li X;Sundquist J;Sundquist K
本研究评估了年龄>39岁首次住院的2型糖尿病患者随后患癌症的风险。24种癌症类型在最后一次因2型糖尿病住院后开始随访时显示出风险升高。在家族性糖尿病患者中没有发现额外的风险。癌症和2型糖尿病（T2 D）是两种可能具有相同风险因素的常见疾病。我们的目的是确定瑞典T2 D住院患者的后续癌症风险。T2 D患者来自全国医院出院登记处;癌症记录来自瑞典癌症登记处。计算末次因T2 D住院后癌症的标准化发病率比（SIR）。对照组是瑞典的一般人口。从1964年到2007年，住院的T2 D患者人数为125，126人，其中26，641人有受影响的家庭成员。在最后一次住院后开始随访时，共有24种癌症显示出风险升高。胰腺癌（6.08）和肝癌（4.25）的SIR最高。在最后一次因T2 D住院后5年开始随访时，这些癌症的发病率甚至升高，原发性肝癌显示出最高的SIR 4.66。上呼吸消化道、食管、结肠、直肠、胰腺、肺、宫颈、子宫内膜、卵巢和肾癌的发病率也有所增加。前列腺癌的风险较低。家族性T2 D患者没有表现出异常升高的癌症风险，但他们的前列腺癌和黑色素瘤风险较低。这项研究覆盖了大约一半的瑞典T2 D患者，显示T2 D住院后几种癌症的风险升高，可能表明基础疾病的严重代谢紊乱。肝癌和胰腺癌的风险最高。在家族性糖尿病患者中没有观察到额外的癌症风险。前列腺癌的低风险仍然很有趣。
The present study assessed subsequent cancer risks in type 2 diabetes patients first hospitalized for this disease at age >39 years. Twenty-four cancer types showed an elevated risk when follow-up was started after the last hospitalization for type 2 diabetes. No additional risk was found in familial diabetics. Cancer and type 2 diabetes (T2D) are two common diseases that may share risk factors. We aimed at determining subsequent cancer risks in patients hospitalized for T2D in Sweden. T2D patients were obtained from the nationwide Hospital Discharge Register; cancers were recorded from the Swedish Cancer Registry. Standardized incidence ratios (SIRs) were calculated for cancer following last hospitalization for T2D. The comparison group was the general Swedish population. The number of hospitalized T2D patients from 1964 to 2007 was 125,126, of whom 26,641 had an affected family member. Altogether 24 cancers showed an elevated risk when follow-up was started after the last hospitalization. The highest SIRs were for pancreatic (6.08) and liver (4.25) cancers. The incidences of these cancers were even elevated when follow-up was started 5 years after the last hospitalization for T2D, with primary liver cancer showing the highest SIR of 4.66. Also increased were the incidences of upper aerodigestive tract, esophageal, colon, rectal, pancreatic, lung, cervical, endometrial, ovarian, and kidney cancers. Prostate cancer showed a lower risk. Familial T2D patients showed no exceptional elevated cancer risks but their prostate cancer and melanoma risks were lower. This study, covering approximately one half of Swedish T2D patients, showed an elevated risk for several cancers after hospitalization for T2D, probably indicating the profound metabolic disturbances of the underlying disease. The highest risks were found for liver and pancreatic cancers. No excess cancer risks were observed in familial diabetics. The lower risk for prostate cancer remains intriguing.
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影响因子：
50.5
作者：
Ji, J.;Shu, X.;Hemminki, K.
通讯作者：
Hemminki, K.
影响因子：
6.4
作者：
Rousseau, MC;Parent, ME;Siemiatycki, J
通讯作者：
Siemiatycki, J
影响因子：
16.2
作者：
Hemminki K;Li X;Sundquist K;Sundquist J
通讯作者：
Sundquist J
影响因子：
5
作者：
Coughlin, SS;Calle, EE;Thun, MJ
通讯作者：
Thun, MJ
影响因子：
8.2
作者：
KAPRIO, J;TUOMILEHTO, J;KESANIEMI, YA
通讯作者：
KESANIEMI, YA