Medial prefrontal cortex and hippocampal activity differentially contribute to ordinal and temporal context retrieval during sequence memory.

Medial prefrontal cortex and hippocampal activity differentially contribute to ordinal and temporal context retrieval during sequence memory.
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DOI:
10.1101/lm.052365.120
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发表时间:
2021-04
期刊:
Learning & memory (Cold Spring Harbor, N.Y.)
影响因子:
--
通讯作者:
Mattfeld AT
Mattfeld AT
中科院分区:
其他
文献类型:
--
作者:
Reeders PC;Hamm AG;Allen TA;Mattfeld AT

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记住事件序列定义了情景记忆,但提取可以由顺序性和时间背景驱动。这些检索模式是否同时起作用仍不清楚。从理论上讲,内侧前额叶皮层(mPFC)赋予的ordinality,而海马体(HC)的相关事件在逐渐变化的时间背景。在这里,我们用BOLD fMRI在一个对两种检索模式都征税的序列任务中寻找每一种模式的证据。为了测试顺序模式,项目在序列之间转移,但保留其位置(例如,AB3)。顺序模式激活mPFC,但不激活HC。为了测试时间上下文,我们检查了跨越滞后距离向前跳过的项目(例如,ABD)。HC,但不是mPFC,跟踪时间背景。存在mPFC和HC通过检索模式相互作用。这些目前的结果表明,mPFC和HC同时从事不同的检索模式,以支持记住事件发生时。
Remembering sequences of events defines episodic memory, but retrieval can be driven by both ordinality and temporal contexts. Whether these modes of retrieval operate at the same time or not remains unclear. Theoretically, medial prefrontal cortex (mPFC) confers ordinality, while the hippocampus (HC) associates events in gradually changing temporal contexts. Here, we looked for evidence of each with BOLD fMRI in a sequence task that taxes both retrieval modes. To test ordinal modes, items were transferred between sequences but retained their position (e.g., AB3). Ordinal modes activated mPFC, but not HC. To test temporal contexts, we examined items that skipped ahead across lag distances (e.g., ABD). HC, but not mPFC, tracked temporal contexts. There was a mPFC and HC by retrieval mode interaction. These current results suggest that the mPFC and HC are concurrently engaged in different retrieval modes in support of remembering when an event occurred.
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