Medial prefrontal cortex and hippocampal activity differentially contribute to ordinal and temporal context retrieval during sequence memory.
Medial prefrontal cortex and hippocampal activity differentially contribute to ordinal and temporal context retrieval during sequence memory.
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DOI:
10.1101/lm.052365.120
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发表时间:
2021-04
期刊:
影响因子:
--
通讯作者:
Mattfeld AT
中科院分区:
文献类型:
--
作者:
Reeders PC;Hamm AG;Allen TA;Mattfeld AT
Remembering sequences of events defines episodic memory, but retrieval can be driven by both ordinality and temporal contexts. Whether these modes of retrieval operate at the same time or not remains unclear. Theoretically, medial prefrontal cortex (mPFC) confers ordinality, while the hippocampus (HC) associates events in gradually changing temporal contexts. Here, we looked for evidence of each with BOLD fMRI in a sequence task that taxes both retrieval modes. To test ordinal modes, items were transferred between sequences but retained their position (e.g., AB3). Ordinal modes activated mPFC, but not HC. To test temporal contexts, we examined items that skipped ahead across lag distances (e.g., ABD). HC, but not mPFC, tracked temporal contexts. There was a mPFC and HC by retrieval mode interaction. These current results suggest that the mPFC and HC are concurrently engaged in different retrieval modes in support of remembering when an event occurred.
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影响因子:
3.5
作者:
Gorgolewski K;Burns CD;Madison C;Clark D;Halchenko YO;Waskom ML;Ghosh SS
通讯作者:
Ghosh SS
DOI:
10.1523/jneurosci.6021-09.2010
发表时间:
2010-05-26
期刊:
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子:
--
作者:
Brown TI;Ross RS;Keller JB;Hasselmo ME;Stern CE
通讯作者:
Stern CE
影响因子:
5.7
作者:
Dale, AM;Fischl, B;Sereno, MI
通讯作者:
Sereno, MI
影响因子:
5.3
作者:
DuBrow, Sarah;Davachi, Lila
通讯作者:
Davachi, Lila
DOI:
10.1093/cercor/bhr264
发表时间:
2012-08
期刊:
Cerebral cortex (New York, N.Y. : 1991)
影响因子:
--
作者:
Benoit RG;Gilbert SJ;Frith CD;Burgess PW
通讯作者:
Burgess PW