Determinants of behavioral and psychological symptoms of dementia: A scoping review of the evidence.

Determinants of behavioral and psychological symptoms of dementia: A scoping review of the evidence.
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DOI:
10.1016/j.outlook.2017.06.006
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发表时间:
2017-09
期刊:
影响因子:
4.3
通讯作者:
Scerpella D
Scerpella D
中科院分区:
医学2区
文献类型:
--
作者:
Kolanowski A;Boltz M;Galik E;Gitlin LN;Kales HC;Resnick B;Van Haitsma KS;Knehans A;Sutterlin JE;Sefcik JS;Liu W;Petrovsky DV;Massimo L;Gilmore-Bykovskyi A;MacAndrew M;Brewster G;Nalls V;Jao YL;Duffort N;Scerpella D

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痴呆的行为和心理症状(BPSD)在神经退行性疾病患者中普遍存在。在这一范围审查Kales,Gitlin和Lykevin框架是用来回答这个问题:什么高质量的证据存在的病人,照顾者和环境的决定因素的五个特定的BPSD:侵略,激动,冷漠,抑郁和精神病?制定了先验审查方案;在检索中检索到的6013篇文章中,有692篇被认为符合审查条件。使用Gough的证据权重框架和科克伦协作组的偏倚风险评估工具。总结了56篇高质量/低偏倚文献的结果。每种症状都有自己的一套决定因素,但许多是常见的几种症状:神经变性,痴呆类型,认知障碍的严重程度,功能能力下降,以及在较小程度上,照顾者的负担和沟通。研究和政策影响与《国家防治阿尔茨海默病计划》有关。
Behavioral and psychological symptoms of dementia (BPSD) are prevalent in people with neurodegenerative diseases. In this scoping review the Kales, Gitlin and Lykestos framework is used to answer the question: What high quality evidence exists for the patient, caregiver and environmental determinants of five specific BPSD: aggression, agitation, apathy, depression and psychosis? An a priori review protocol was developed; 692 of 6013 articles retrieved in the search were deemed eligible for review. Gough’s Weight of Evidence Framework and the Cochrane Collaboration’s tool for assessing risk of bias were used. The findings from 56 high quality/low bias articles are summarized. Each symptom had its own set of determinants, but many were common across several symptoms: neurodegeneration, type of dementia, severity of cognitive impairments, and declining functional abilities, and to a lesser extent, caregiver burden and communication. Research and policy implications are relevant to the National Plan to Address Alzheimer’s Disease.
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