The familial transmission of primary major depressive disorder.
The familial transmission of primary major depressive disorder.
复制标题
原发性重度抑郁症的家族传播。
DOI：
10.1016/0022-3956(87)90112-9
复制
发表时间：
1987
影响因子：
4.8
通讯作者：
Klerman,GL
中科院分区：
文献类型：
--
作者：
Reich,T;VanEerdewegh,P;Rice,J;Mullaney,J;Endicott,J;Klerman,GL
这是一项在NIMH-CRB协作抑郁项目中确定的235名患有原发性重度抑郁症的先证者家庭中进行的原发性重度抑郁症家族传播的研究。其中包括826名受访的一级亲属和109名配偶。研究诊断标准已被使用，并使用SADS-L schedule.Prior这些数据的分析已经建立了强大的长期趋势的发病年龄和患病率的抑郁症在这些家庭中进行了采访。因此，新的方法来分析家庭数据，其中包括长期的variation.Non-parametric生存分析，使用考克斯比例风险模型，指导制定了一个定量的家庭传播模型。采用多因素疾病传播模型和Tau路径分析模型进行家系分析，非参数分析发现，只有同胞出生队列、母亲性别和情感状况与同胞发病时间有显著相关。先证者的性别、发病年龄和父亲是否患病均无显著性差异。定量分析证实，最近出生的人群中，原发性重度抑郁症的预期终生患病率增加，发病年龄降低。配对是目前和环境因素共同的兄弟姐妹没有作出显着贡献的表型方差。发现了性别特异性传递，女性的传递率（t2= 0.62）显著大于男性（t2= 0.28）。有一种趋势，即原发性重度抑郁症的遗传性在最近出生的队列中更大。
This is a study of the familial transmission of Primary Major Depressive Disorder in the families of 235 probands with this disorder ascertained as part of the NIMH-CRB Collaborative Depression Program. Eight hundred and twenty-six interviewed first degree relatives and 109 spouses are included. Research Diagnostic Criteria have been used and interviews were done using the SADS-L schedule.Prior analyses of these data have established the presence of strong secular trends in the age-of-onset and prevalence of Major Depressive Disorder in these families. Accordingly, new methods for the analysis of family data which incorporate secular variation were developed.Non-parametric Survival Analysis, using the Cox Proportional Hazards Model, guided the formulation of a quantitative family transmission model. Then a family analysis was conducted with the Multifactorial Model of Disease Transmission and the Tau Path Analytic Model.Using the non-parametric approach, only the sibs birth cohort, sex and affectational status of the mother were significantly related to the time of onset of illness in siblings. Proband sex, age-of-onset, and the presence of illness in the father were not significant.The quantitative analysis confirmed that more recently born cohorts of individuals had an increased expected lifetime prevalence and a decreased age-of-onset of Primary Major Depressive Disorder. Assortative mating was present and environmental factors common to siblings did not make a significant contribution to the phenotypic variance. Sex specific transmissibilities were found and the transmissibility in females (t2= 0.62) was significantly greater than that of males (t2= 0.28). There was a trend for the transmissibility of Primary Major Depressive Disorder to be greater in more recently born cohorts.
登录
查看更多内容
影响因子：
--
作者：
M. Weissman;K. Kidd;B. Prusoff
通讯作者：
M. Weissman;K. Kidd;B. Prusoff
家庭相似性与时间趋势的路径分析：在巴西东北部身高、体重和 Quetelet 指数的应用。
影响因子：
9.8
作者：
Province,MA;Rao,DC
通讯作者：
Rao,DC
情感障碍患者亲属中重度抑郁症发病率的出生队列趋势。
影响因子：
--
作者：
Klerman,GL;Lavori,PW;Rice,J;Reich,T;Endicott,J;Andreasen,NC;Keller,MB;Hirschfield,RM
通讯作者：
Hirschfield,RM
影响因子：
--
作者：
N. Andreasen;J. Rice;J. Endicott;W. Coryell;W. Grove;T. Reich
通讯作者：
T. Reich
成年早期出现严重抑郁症。
影响因子：
--
作者：
Weissman,MM;Wickramaratne,P;Merikangas,KR;Leckman,JF;Prusoff,BA;Caruso,KA;Kidd,KK;Gammon,GD
通讯作者：
Gammon,GD