Vitamin D status is associated with arterial stiffness and vascular dysfunction in healthy humans.
Vitamin D status is associated with arterial stiffness and vascular dysfunction in healthy humans.
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DOI：
10.1016/j.jacc.2011.02.051
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发表时间：
2011-07-05
影响因子：
24
通讯作者：
Quyyumi, Arshed A.
中科院分区：
文献类型：
--
作者：
Al Mheid, Ibhar;Patel, Riyaz;Murrow, Jonathan;Morris, Alanna;Rahman, Ayaz;Fike, Lucy;Kavtaradze, Nino;Uphoff, Irina;Hooper, Craig;Tangpricha, Vin;Alexander, R. Wayne;Brigham, Kenneth;Quyyumi, Arshed A.
本研究的主要目的是通过探索25-羟基维生素D（25-OH D）（维生素D状态的一种既定标志物）与健康成人血管功能之间的关系，阐明维生素D状态与心血管疾病之间联系的潜在机制。维生素D缺乏介导的心血管疾病风险增加的潜在机制仍然未知。维生素D影响内皮和平滑肌细胞功能，介导炎症，并调节肾素-血管紧张素-醛固酮轴。我们研究了人体维生素D状态与血管功能之间的关系，假设维生素D不足与动脉僵硬度增加和血管功能异常有关。我们测定了554例受试者的血清25-OH D。以肱动脉血流介导的舒张功能评价内皮功能，以手指反应性充血指数评价微血管功能。测量颈动脉-股动脉脉搏波速度和桡动脉张力计导出的中央增强指数和内膜下存活率以评估动脉硬度。平均25-OH D为31.8 ± 14 ng/ml。校正年龄、性别、种族、体重指数、总胆固醇、低密度脂蛋白、甘油三酯、C反应蛋白和药物使用后，25-OH D仍然与血流介导的血管舒张独立相关（β = 0.1，p = 0.03），反应性充血指数（β = 0.23，p < 0.001），脉搏波速度（β =-0.09，p = 0.04）、增强指数（β =-0.11，p = 0.03）和内膜下存活率（β = 0.18，p = 0.001）。在42例维生素D不足的受试者中，6个月时25-OH D正常化与反应性充血指数（0.38 ± 0.14，p = 0.009）和内膜下存活率（7.7 ± 3.1，p = 0.04）增加以及平均动脉压降低（4.6 ± 2.3 mm Hg，p = 0.02）相关。维生素D不足与人类传导和阻力血管中动脉僵硬度增加和内皮功能障碍有关，与传统的风险负担无关。我们的发现为更大规模的试验提供了动力，以评估维生素D治疗对心血管疾病的影响。
The primary objective of this study was to elucidate mechanisms underlying the link between vitamin D status and cardiovascular disease by exploring the relationship between 25-hydroxyvitamin D (25-OH D), an established marker of vitamin D status, and vascular function in healthy adults. Mechanisms underlying vitamin D deficiency-mediated increased risk of cardiovascular disease remain unknown. Vitamin D influences endothelial and smooth muscle cell function, mediates inflammation, and modulates the renin-angiotensin-aldosterone axis. We investigated the relationship between vitamin D status and vascular function in humans, with the hypothesis that vitamin D insufficiency will be associated with increased arterial stiffness and abnormal vascular function. We measured serum 25-OH D in 554 subjects. Endothelial function was assessed as brachial artery flow-mediated dilation, and microvascular function was assessed as digital reactive hyperemia index. Carotid-femoral pulse wave velocity and radial tonometry-derived central augmentation index and subendocardial viability ratio were measured to assess arterial stiffness. Mean 25-OH D was 31.8 ± 14 ng/ml. After adjustment for age, sex, race, body mass index, total cholesterol, low-density lipoprotein, triglycerides, C-reactive protein, and medication use, 25-OH D remained independently associated with flow-mediated vasodilation (β = 0.1, p = 0.03), reactive hyperemia index (β = 0.23, p < 0.001), pulse wave velocity (β = −0.09, p = 0.04), augmentation index (β = −0.11, p = 0.03), and subendocardial viability ratio (β = 0.18, p = 0.001). In 42 subjects with vitamin D insufficiency, normalization of 25-OH D at 6 months was associated with increases in reactive hyperemia index (0.38 ± 0.14, p = 0.009) and subendocardial viability ratio (7.7 ± 3.1, p = 0.04), and a decrease in mean arterial pressure (4.6 ± 2.3 mm Hg, p = 0.02). Vitamin D insufficiency is associated with increased arterial stiffness and endothelial dysfunction in the conductance and resistance blood vessels in humans, irrespective of traditional risk burden. Our findings provide impetus for larger trials to assess the effects of vitamin D therapy in cardiovascular disease.
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影响因子：
37.8
作者：
Benjamin, EJ;Larson, MG;Vita, JA
通讯作者：
Vita, JA
影响因子：
13.6
作者：
London, Gerard M.;Guerin, Alain P.;Metivier, Fabien
通讯作者：
Metivier, Fabien
DOI：
10.2215/cjn.00900208
发表时间：
2008-11-01
影响因子：
9.8
作者：
Andrade, Jason;Er, Lee;Levin, Adeera
通讯作者：
Levin, Adeera
影响因子：
24
作者：
Kitta, Yoshinobu;Obata, Jyun-ei;Kugiyama, Kiyotaka
通讯作者：
Kugiyama, Kiyotaka
影响因子：
--
作者：
Melamed, Michal L.;Michos, Erin D.;Post, Wendy;Astor, Brad
通讯作者：
Astor, Brad