Cognitive deficits in recent-onset and chronic schizophrenia.
Cognitive deficits in recent-onset and chronic schizophrenia.
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最近发病和慢性精神分裂症的认知缺陷。
DOI：
10.1016/j.jpsychires.2009.09.010
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发表时间：
2010-05
影响因子：
4.8
通讯作者：
Schulz SC
中科院分区：
文献类型：
--
作者：
Sponheim SR;Jung RE;Seidman LJ;Mesholam-Gately RI;Manoach DS;O'Leary DS;Ho BC;Andreasen NC;Lauriello J;Schulz SC
虽然认知功能障碍是精神分裂症的主要特征，但直到最近才开始进行调查，以确定患有这种疾病的个体何时出现功能障碍。迄今为止的研究提供了在疾病发作之前存在显著认知障碍的证据。对精神分裂症从发病到慢性期认知功能障碍的过程知之甚少。虽然纵向研究是最佳的认知缺陷的稳定性评估，实践效果往往混淆的评估，并没有大的和有代表性的受试者样本进行了长时间的跟踪。我们报告了一项在四个不同地理位置进行的精神分裂症早期和晚期认知缺陷的横断面研究结果，以增加样本量和结果的普遍性。我们研究了41例新发精神分裂症患者和106例慢性精神分裂症患者的广泛认知功能。该研究包括43个匹配对照的单独组用于最近发作的样品和105个匹配对照的慢性精神分裂症样品，以评估队列的影响（即，年龄）和诊断（即，精神分裂症）对认知功能的影响。认知功能的所有措施显示诊断的影响，但是，选择基于时间的解决问题和精细运动灵活性的措施表现出诊断和队列的相互作用，表明这些赤字可能会超出预期的正常老化。此外，更糟糕的回忆材料的情节记忆与更长的疾病。然而，研究结果表明，几乎所有的认知缺陷都是近期发作和慢性精神分裂症的共同损害。
Although cognitive dysfunction is a primary characteristic of schizophrenia, only recently have investigations begun to pinpoint when the dysfunction develops in the individual afflicted by the disorder. Research to date provides evidence for significant cognitive impairments prior to disorder onset. Less is known about the course of cognitive dysfunction from onset to the chronic phase of schizophrenia. Although longitudinal studies are optimal for assessing stability of cognitive deficits, practice effects often confound assessments, and large and representative subject samples have not been followed over long periods of time. We report results of a cross-sectional study of cognitive deficits early and late in the course of schizophrenia carried out at four different geographic locations to increase sample size and generalizability of findings. We examined a broad set of cognitive functions in 41 recent-onset schizophrenia patients and 106 chronic schizophrenia patients. The study included separate groups of 43 matched controls for the recent-onset sample and 105 matched controls for the chronic schizophrenia sample in order to evaluate the effects of cohort (i.e., age) and diagnosis (i.e., schizophrenia) on cognitive functions. All measures of cognitive function showed effects of diagnosis; however, select time-based measures of problem solving and fine motor dexterity exhibited interactions of diagnosis and cohort indicating that these deficits may progress beyond what is expected with normal aging. Also, worse recall of material in episodic memory was associated with greater length of illness. Nevertheless, findings indicate that nearly all cognitive deficits are comparably impaired across recent-onset and chronic schizophrenia.
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影响因子：
4.5
作者：
Hawkins, Keith A.;Keefe, Richard S. E.;McGlashan, Thomas H.
通讯作者：
McGlashan, Thomas H.
影响因子：
3.3
作者：
Kurtz, MM;Seltzer, JC;Wexler, BE
通讯作者：
Wexler, BE
影响因子：
4.5
作者：
Kurtz, MM
通讯作者：
Kurtz, MM
影响因子：
10.6
作者：
Harvey, PD;Silverman, JM;Davis, KL
通讯作者：
Davis, KL
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4.5
作者：
Bowie, Christopher R.;Reichenberg, Abraham;Harvey, Philip D.
通讯作者：
Harvey, Philip D.