Association of multiple primary melanomas with malignancy risk: A population-based analysis of entries from the Surveillance, Epidemiology, and End Results program database during 1973-2014.
Association of multiple primary melanomas with malignancy risk: A population-based analysis of entries from the Surveillance, Epidemiology, and End Results program database during 1973-2014.
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多发性原发性黑色素瘤与恶性肿瘤风险的相关性：1973-2014年期间监测，流行病学和最终结果计划数据库条目的基于人群的分析。
DOI：
10.1016/j.jaad.2018.09.027
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发表时间：
2023-05
影响因子：
13.8
通讯作者：
Sarin, Kavita Y.
中科院分区：
文献类型：
--
作者：
Cai, Emily D.;Swetter, Susan M.;Sarin, Kavita Y.
关键词：
遗传和环境风险因素与多发性原发性黑色素瘤（MPM）的发生有关。我们假设MPM患者可能有更高的发生内部恶性肿瘤的倾向。确定MPM患者后续恶性肿瘤的风险。分析了1973-2014年SEER数据库中≥1、≥2和≥3例原发性黑色素瘤（PM）个体的多个主要标准化发病率比。确定了223，799例≥1 PM、19，709例≥2 PM和3，995例≥3 PM的个体。后续内部恶性肿瘤的风险随着PM的数量而增加，对于至少有一个，两个和三个PM的患者，观察到的与预期的（O/E）比值分别为0.99，1.14和1.23（p<0.05）。年轻的MPM患者和浅表扩散性黑色素瘤患者的内部恶性程度较高。MPM患者中最常见的恶性肿瘤包括乳腺、前列腺、甲状腺、软组织、脑、肾、非霍奇金淋巴瘤和慢性淋巴细胞白血病。O/E比值分别为8.09、22.52、41.03（p<0.05）时，后续皮肤黑色素瘤的风险增加。SEER记录了关于色素沉着表型、组织学和治疗的有限信息。MPM患者有后续内部和皮肤恶性肿瘤的风险增加，并可能受益于严格遵守年龄特异性癌症筛查。
Genetic and environmental risk factors have been associated with the development of multiple primary melanomas (MPM). We hypothesized that individuals with MPM may have increased predisposition to developing internal malignancies. To identify the risk of subsequent malignancies in MPM patients. Multiple primary standardized incidence ratios were analyzed for individuals with ≥1, ≥2 and ≥3 primary melanomas (PM) in the SEER database from 1973-2014. 223,799 individuals with ≥1, 19,709 with ≥2 and 3,995 with ≥3 PM were identified. Risks of subsequent internal malignancy increased with number of PM, with observed to expected (O/E) ratios of 0.99, 1.14, and 1.23 (p<0.05) for patients with at least one, two and three PM respectively. Internal malignancy was higher in younger MPM patients and those with superficial spreading melanoma. The most common malignancies amongst MPM patients include breast, prostate, thyroid, soft tissue, brain, kidney, non-Hodgkin's lymphoma, and chronic lymphocytic leukemia. Risk of subsequent cutaneous melanoma increased with O/E ratios of 8.09, to 22.52, to 41.03 (p<0.05) respectively. SEER records limited information about pigmentation phenotypes, histology, and treatments. Patients with MPM have increased risk of subsequent internal and cutaneous malignancies and may benefit from tight adherence to age-specific cancer screening.
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影响因子：
64.8
作者：
Bertolotto, Corine;Lesueur, Fabienne;Bressac-de Paillerets, Brigitte
通讯作者：
Bressac-de Paillerets, Brigitte
影响因子：
--
作者：
Bradford, Porcia T.;Freedman, Michal;Goldstein, Alisa M.;Tucker, Margaret A.
通讯作者：
Tucker, Margaret A.
DOI：
10.1158/1055-9965.epi-14-1426
发表时间：
2015-06
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
Gibbs DC;Orlow I;Kanetsky PA;Luo L;Kricker A;Armstrong BK;Anton-Culver H;Gruber SB;Marrett LD;Gallagher RP;Zanetti R;Rosso S;Dwyer T;Sharma A;La Pilla E;From L;Busam KJ;Cust AE;Ollila DW;Begg CB;Berwick M;Thomas NE;GEM Study Group
通讯作者：
GEM Study Group
影响因子：
4
作者：
Bubien, Virginie;Bonnet, Francoise;Caux, Frederic
通讯作者：
Caux, Frederic
影响因子：
120.7
作者：
Ferrone, CR;Ben Porat, L;Coit, DG
通讯作者：
Coit, DG