Increased risk of second primary cancers after a diagnosis of melanoma.
Increased risk of second primary cancers after a diagnosis of melanoma.
复制标题
DOI：
10.1001/archdermatol.2010.2
复制
发表时间：
2010-03
影响因子：
--
通讯作者：
Tucker, Margaret A.
中科院分区：
文献类型：
--
作者：
Bradford, Porcia T.;Freedman, Michal;Goldstein, Alisa M.;Tucker, Margaret A.
量化原发性皮肤恶性黑色素瘤患者随后发生原发性癌症的风险。基于人群的登记研究。我们评估了1973-2006年监测、流行病学和最终结果项目的9个癌症登记处的数据。我们纳入了89515例患者，他们在最初的黑色素瘤诊断后至少存活了2个月。在黑色素瘤患者中，10857例（12.1%）发生了1种或多种原发性癌症。后续原发性癌症的总体风险增加了28%（观察与预期[O：E]比值=1.28）。四分之一的癌症是随后的原发性黑色素瘤（O：E=8.61）。患有头颈部黑色素瘤的女性和年龄小于30岁的患者发生后续黑色素瘤的风险显著增加（O：E=13.22和13.40，分别）。第二个黑色素瘤比第一个多原发性黑色素瘤更可能薄（诊断时厚度<1.00 mm，分别为77.9%和70.3%; P<0.001）。黑色素瘤幸存者患几种癌症的风险增加;风险增加的最常见癌症是乳腺癌、前列腺癌和非霍奇金淋巴瘤（O：E=1.10、1.15和1.25）。与一般人群相比，黑色素瘤幸存者发生后续黑色素瘤的风险增加约9倍。在最初的黑色素瘤诊断后超过20年，风险仍然升高。这种增加的风险可能是由于行为因素，遗传易感性或医疗监督。虽然随后的原发性黑色素瘤的厚度大于1 mm的百分比低于第一个多原发性黑色素瘤，但它仍然很大。黑色素瘤幸存者应继续监测，不仅复发，而且为未来的原发性黑色素瘤和其他癌症。
To quantify the risk of subsequent primary cancers among patients with primary cutaneous malignant melanoma. Population-based registry study. We evaluated data from 9 cancer registries of the Surveillance, Epidemiology, and End Results program from 1973–2006. We included 89 515 patients who survived at least 2 months after their initial melanoma diagnosis. Of the patients with melanoma, 10 857 (12.1%) developed 1 or more subsequent primary cancers. The overall risk of a subsequent primary cancer increased by 28% (observed to expected [O:E] ratio=1.28). One quarter of the cancers were subsequent primary melanomas (O:E=8.61). Women with head and neck melanoma and patients younger than 30 had markedly increased risks (O:E=13.22 and 13.40, respectively) of developing a subsequent melanoma. Second melanomas were more likely to be thin than were the first of multiple primary melanomas (thickness at diagnosis <1.00mm, 77.9% vs 70.3%, respectively; P<.001). Melanoma survivors had increased risk of developing several cancers; the most common cancers with elevated risks were breast, prostate, and non-Hodgkin lymphoma (O:E=1.10, 1.15, and 1.25, respectively). Melanoma survivors have an approximately 9-fold increased risk of developing subsequent melanoma compared with the general population. The risk remains elevated more than 20 years after the initial melanoma diagnosis. This increased risk may be owing to behavioral factors, genetic susceptibility, or medical surveillance. Although the percentage of subsequent primary melanomas thicker than 1 mm is lower than for the first of multiple primary melanomas, it is still substantial. Melanoma survivors should remain under surveillance not only for recurrence but also for future primary melanomas and other cancers.
登录
查看更多内容
影响因子：
6.4
作者：
Goggins, W;Gao, W;Tsao, H
通讯作者：
Tsao, H
影响因子：
3.7
作者：
Brobeil, A;Rapaport, D;Reintgen, DS
通讯作者：
Reintgen, DS
影响因子：
6.2
作者：
Inskip, PD
通讯作者：
Inskip, PD
影响因子：
2.2
作者：
GILES, G;STAPLES, M;COATES, M
通讯作者：
COATES, M
影响因子：
3.8
作者：
Goldstein, AM;Landi, MT;Tucker, MA
通讯作者：
Tucker, MA