Ossifying Fibromyxoid tumor of soft parts in head and neck: case report and literature review.
Ossifying Fibromyxoid tumor of soft parts in head and neck: case report and literature review.
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头颈部软组织骨化性纤维粘液瘤病例报告及文献复习
DOI：
10.1186/s13000-018-0699-7
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发表时间：
2018-03-27
影响因子：
2.6
通讯作者：
Wang D
中科院分区：
文献类型：
--
作者：
Velasco IA;Zhang R;Li T;Wang D
软组织骨化性纤维粘液样肿瘤（OFMT）是一种少见的、形态学上独特的肿瘤，其组织发生机制尚不清楚，好发于中年男性。临床上，它通常表现为一个缓慢扩大的，小的，局限性肿块，在大多数情况下是无痛的。OFMT最常见于四肢或躯干的皮下组织，很少出现在口腔/头部和颈部区域。我们提出了一个不寻常的情况下，这种肿瘤在下颌下区域，并根据目前的医学文献，这可能是第一次在这种解剖location.Case presentationA 32岁的男性介绍了我们的门诊诊所与右下颌下肿块1年的演变。切除活检显示其特征为沿病变周边沿着骨化。肿瘤细胞呈梭形，胞浆嗜酸性少。这些细胞以均匀的细胞间空间排列在纤维粘液样基质中。肿瘤内可见大小不等的钙化灶。免疫组化示S-100蛋白、波形蛋白、巢蛋白、钙调蛋白、SMA、GFAF、结蛋白、INI-1、钙调蛋白、CD 34阳性表达。CK、CK 7、CK 8/18、NF、EMA均为阴性。约2%的肿瘤细胞呈Ki 67阳性染色。基于这些功能，最终的病理诊断是OFMT.ConclusionsIt希望，更好地了解OFMT的头部和颈部区域将避免潜在的误诊，并有助于确定正确的管理，这似乎是完整的手术切除密切随访复发监测。
BackgroundOssifying fibromyxoid tumor of soft parts (OFMT), is a rare but morphologically distinctive neoplasm of uncertain histogenesis that most frequently affects middle-aged male adults. Clinically, it usually presents as a slowly enlarging, small, circumscribed mass, which in most cases is painless. OFMT is most frequently found within the subcutaneous tissues of extremities or trunk, and rarely in the oral/head and neck region. We present an unusual case of this tumor in the submandibular region, and, based on the current medical literatures this is probably the first case described in this anatomical location.Case presentationA 32-year-old male presented to our outpatient clinic with a right submandibular mass with 1-year of evolution. Excisional biopsy showed that it was characterized by ossification along the periphery of the lesion. The neoplastic cells were spindle-like with scant eosinophilic cytoplasm. These cells were arranged with uniform cell-to-cell space in a fibromyxoid stroma. Small and large clusters of calcifications were present within the tumor. Immunohistochemically, the case showed positive staining of S-100 protein, vimentin, nestin, calponin, SMA, GFAF, desmin, INI-1, caldesmon, and CD34. It also showed negative staining of CK, CK7, CK8/18, NF, and EMA. About 2% of neoplastic cells showed positive staining of Ki67. Based on these features, the final pathological diagnosis was OFMT.ConclusionsIt is hoped that a greater understanding of OFMT in the head and neck region will avoid potential misdiagnosis, and contribute to determining the correct management, which appears to be complete surgical excision with close follow-up for recurrence surveillance.
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影响因子：
2.8
作者：
LAX, SF;RATSCHEK, M;BEHAM, A
通讯作者：
BEHAM, A
影响因子：
4.3
作者：
Nonaka, Cassiano F. W.;Pacheco, Domingos F. S.;da Costa Miguel, Marcia Cristina
通讯作者：
da Costa Miguel, Marcia Cristina
影响因子：
3
作者：
Ohta K;Taki M;Ogawa I;Ono S;Mizuta K;Fujimoto S;Takata T;Kamata N
通讯作者：
Kamata N
影响因子：
5.6
作者：
Graham, Rondell P.;Weiss, Sharon W.;Folpe, Andrew L.
通讯作者：
Folpe, Andrew L.
影响因子：
3.3
作者：
DONNER, LR
通讯作者：
DONNER, LR