Cohort analysis of cigarette smoking and lung cancer incidence among Norwegian women.
Cohort analysis of cigarette smoking and lung cancer incidence among Norwegian women.
复制标题
挪威女性吸烟与肺癌发病率的队列分析。
DOI：
--
复制
发表时间：
1999
影响因子：
7.7
通讯作者：
T. Grimsrud
中科院分区：
文献类型：
--
作者：
Tor Haldorsen;T. Grimsrud
背景
癌症登记处几十年来一直在调查癌症疾病的发展。事件案例数据包括人口统计变量。了解风险因素在相同变量上的时间分布，就有可能建立疾病与风险因素之间关系的模型。这种分析的结果可能很难解释，因为它们是以综合数据为基础的。但这些数据来源的可用性应鼓励进一步探索其可能性和局限性。
方法
建立了1890-1949年5岁出生队列中吸烟习惯的时间模式，并提供了关于目前吸烟者、以前吸烟者和不吸烟者的比例以及估计的平均每日烟草消费量和平均吸烟持续时间的数据。通过一个模型分析了1953-1992年队列中的肺癌发病率，该模型包括取决于每日吸烟剂量和吸烟持续时间的吸烟者的额外风险。
结果
该模型充分描述了后来几十年的肺癌发病率，该模型显示了与队列中吸烟行为的简单关系。对于目前的吸烟者和以前的吸烟者，超额风险与每日吸烟量和吸烟持续时间的4.5次方成正比。非吸烟者的年龄特异性比率接近年龄的五次幂曲线。
结论
即使肺癌的发病率没有单独确定组已知的吸烟习惯，合理的估计吸烟的影响，可以得出，如果适当的信息，在人群中的时间吸烟习惯。
BACKGROUND
Cancer registries have for decades surveyed the development of cancer diseases. Data on incident cases includes demographic variables. Knowledge of the temporal distribution of risk factors on the same variables makes it possible to model the relationship between disease and risk factor. The results of such analyses might be difficult to interpret since they are based on aggregated data. But the availability of these data sources should encourage further exploration of its possibilities and limitations.
METHODS
The temporal pattern of smoking habits in 5-year birth cohorts from 1890-1949 was established, with data on the proportions of current smokers, former smokers and non-smokers and estimated average daily consumption of tobacco and average duration of smoking. The lung cancer incidence among the cohorts in 1953-1992 was analysed by a model which included an additive excess risk for smokers that depended on daily dose and duration of smoking.
RESULTS
The lung cancer incidence in later decades was adequately described by the model, which showed a simple relationship with smoking behaviour in the cohorts. For both current smokers and former smokers, the excess risk was about proportional to the daily amount smoked and the 4.5 power of duration of smoking. The age-specific rates for non-smokers were close to a fifth-power curve of age.
CONCLUSIONS
Even if lung cancer incidence is not determined separately for groups with known smoking habits, plausible estimates of the effect of smoking can be derived if appropriate information is available on temporal smoking habits in the population.
影响因子：
10.3
作者：
Zang, EA;Wynder, EL
通讯作者：
Wynder, EL
影响因子：
2
作者：
Whittemore,AS
通讯作者：
Whittemore,AS
吸烟对康涅狄格州肺癌发病率影响的模型。
DOI：
10.1002/(sici)1097-0258(19960330)15:6
发表时间：
1996
期刊：
Statistics in medicine.
影响因子：
--
作者：
Holford,TR;Zhang,Z;Zheng,T;McKay,LA
通讯作者：
McKay,LA