A Reliable and Rapid Language Tool for the Diagnosis, Classification, and Follow-Up of Primary Progressive Aphasia Variants.
A Reliable and Rapid Language Tool for the Diagnosis, Classification, and Follow-Up of Primary Progressive Aphasia Variants.
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DOI：
10.3389/fneur.2020.571657
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发表时间：
2020
影响因子：
3.4
通讯作者：
Teichmann M
中科院分区：
文献类型：
--
作者：
Epelbaum S;Saade YM;Flamand Roze C;Roze E;Ferrieux S;Arbizu C;Nogues M;Azuar C;Dubois B;Tezenas du Montcel S;Teichmann M
背景资料：原发性进行性失语症（PPA）已通过临床，治疗和基础研究进行了研究，但缺乏检查员一致的语言测试，以进行可靠的可重复的诊断和随访。研究方法：我们开发并评估了PPA的快速语言测试（“巴黎”），评估其检查者间的一致性，其检测和分类PPA的能力，以及其在随访9个月后识别语言衰退的能力。为了探索该测试的可靠性和特异性/灵敏度，将其应用于PPA患者（N = 36）、典型的遗忘型阿尔茨海默病（AD）患者（N = 24）和健康对照（N = 35），同时将其与用于中风诱导的失语症的两种快速检查者一致的语言测试（“LAST”、“ART”）进行比较。结果：“巴黎”评分持续时间约为10 min，评分者间一致性为88%。这三种测试将健康对照与AD和PPA患者区分开，但只有“巴黎”可靠地将PPA与AD分开，并允许对两种最常见的PPA变体进行分类：语义PPA和逻辑开放PPA。与“LAST”和“ART”相比，“巴黎”在检测语言能力下降方面也具有最高的灵敏度。结论：“巴黎”是一种高效、快速、高度一致的语言测试，用于诊断、分类和随访常见的PPA变体。它也可能是一个有价值的工具，为未来的PPA和其他影响语言处理的神经退行性疾病的治疗试验提供终点。
Background: Primary progressive aphasias (PPA) have been investigated by clinical, therapeutic, and fundamental research but examiner-consistent language tests for reliable reproducible diagnosis and follow-up are lacking. Methods: We developed and evaluated a rapid language test for PPA (“PARIS”) assessing its inter-examiner consistency, its power to detect and classify PPA, and its capacity to identify language decline after a follow-up of 9 months. To explore the reliability and specificity/sensitivity of the test it was applied to PPA patients (N = 36), typical amnesic Alzheimer's disease (AD) patients (N = 24) and healthy controls (N = 35), while comparing it to two rapid examiner-consistent language tests used in stroke-induced aphasia (“LAST”, “ART”). Results: The application duration of the “PARIS” was ~10 min and its inter-rater consistency was of 88%. The three tests distinguished healthy controls from AD and PPA patients but only the “PARIS” reliably separated PPA from AD and allowed for classifying the two most frequent PPA variants: semantic and logopenic PPA. Compared to the “LAST” and “ART,” the “PARIS” also had the highest sensitivity for detecting language decline. Conclusions: The “PARIS” is an efficient, rapid, and highly examiner-consistent language test for the diagnosis, classification, and follow-up of frequent PPA variants. It might also be a valuable tool for providing end-points in future therapeutic trials on PPA and other neurodegenerative diseases affecting language processing.
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影响因子：
9.9
作者：
Sarazin, M.;Berr, C.;Dubois, B.
通讯作者：
Dubois, B.
影响因子：
14.5
作者：
Leyton, Cristian E.;Villemagne, Victor L.;Hodges, John R.
通讯作者：
Hodges, John R.
影响因子：
3.3
作者：
Catricala, Eleonora;Gobbi, Elena;Garrard, Peter
通讯作者：
Garrard, Peter
影响因子：
3.4
作者：
Routier, Alexandre;Habert, Marie-Odile;Teichmann, Marc
通讯作者：
Teichmann, Marc
影响因子：
2.4
作者：
Kertesz, A.;Morlog, D.;Brashear, R.
通讯作者：
Brashear, R.