Targeting heparin and heparan sulfate protein interactions.
Targeting heparin and heparan sulfate protein interactions.
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靶向肝素和乙酰硫酸肝素蛋白相互作用。
DOI：
10.1039/c7ob01058c
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发表时间：
2017-07-21
影响因子：
3.2
通讯作者：
Tor Y
中科院分区：
文献类型：
--
作者：
Weiss RJ;Esko JD;Tor Y
肝素和硫酸肝素糖胺聚糖是由高度硫酸化的糖醛酸和氨基糖交替的双糖序列组成的长线性多糖。与肝素不同，肝素只存在于肥大细胞中，硫酸肝素在所有动物细胞的细胞表面和细胞外基质中普遍表达。这些带负电荷的碳水化合物链在细胞生长、粘附、血管生成和血液凝固等重要细胞功能中起着至关重要的作用。然而，这些生物分子也参与病理生理条件，如病原体感染和人类疾病。本文综述了过去和现在针对这些复杂生物分子的方法，作为治疗癌症、神经退行性疾病和感染等疾病的一种新的治疗策略。硫酸乙酰肝素在所有动物细胞的细胞表面和细胞外基质中普遍表达。这些带负电荷的碳水化合物链通过与各种硫酸肝素结合蛋白（HSBP）相互作用，在细胞生长、粘附、血管生成和血液凝固等重要细胞功能中发挥重要作用。本文综述了靶向这些复杂生物分子的方法，作为治疗癌症、神经退行性疾病和感染等疾病的策略。
Heparin and heparan sulfate glycosaminoglycans are long, linear polysaccharides that are made up of alternating dissacharide sequences of highly sulfated uronic acid and amino sugars. Unlike heparin, which is only found in mast cells, heparan sulfate is ubiquitously expressed on the cell surface and in the extracellular matrix of all animal cells. These negatively-charged carbohydrate chains play essential roles in important cellular functions such as cell growth, adhesion, angiogenesis, and blood coagulation. However, these biomolecules are also involved in pathophysiological conditions such as pathogen infection and human disease. This review discusses past and current methods for targeting these complex biomolecules as a novel therapeutic strategy to treating disorders such as cancer, neurodegenerative diseases, and infection. Heparan sulfate is ubiquitously expressed on the cell surface and in the extracellular matrix of all animal cells. These negatively-charged carbohydrate chains play essential roles in important cellular functions such as cell growth, adhesion, angiogenesis, and blood coagulation by interacting with various heparan sulfate binding proteins (HSBP). This review discusses methods for targeting these complex biomolecules, as a strategy for treating disorders such as cancer, neurodegenerative diseases, and infection.
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影响因子：
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作者：
Bendas G;Borsig L
通讯作者：
Borsig L
影响因子：
3.7
作者：
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通讯作者：
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影响因子：
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作者：
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15
作者：
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通讯作者：
Boons, Geert-Jan
影响因子：
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作者：
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通讯作者：
Emerson, CP