Impact of 2009 pandemic influenza among Vietnamese children based on a population-based prospective surveillance from 2007 to 2011.
Impact of 2009 pandemic influenza among Vietnamese children based on a population-based prospective surveillance from 2007 to 2011.
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DOI：
10.1111/irv.12244
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发表时间：
2014-07
影响因子：
4.4
通讯作者：
Ariyoshi K
中科院分区：
文献类型：
--
作者：
Le MN;Yoshida LM;Suzuki M;Nguyen HA;Le HT;Moriuchi H;Dang DA;Ariyoshi K
流感病毒是引起儿童急性呼吸道感染(ARI)的主要病原体之一。2009年甲型H1N1流感大流行在全球蔓延，对全球健康产生了巨大影响。目的探讨甲型H1N1流感pdm09对越南儿童急性呼吸窘迫综合征的影响。在越南中部进行了持续的基于人群的前瞻性监测。研究对象是2007年2月至2011年3月居住在芽庄市、在清华综合医院ARI监测中登记的所有15岁儿童。收集临床资料和鼻咽拭子标本。采用多重聚合酶链式反应和测序方法对甲型流感病毒进行检测和基因分型。在登记的2736例住院ARI病例中，354例(13%)甲型流感阳性。基因分型结果显示，在2009年7月甲型H1N1流感pdm09出现之前，季节性H3N1和H1N1(SEA-H1N1)病毒正在共存。甲型H1N1流感大流行后，pdm09取代了SEA-H1N1。甲型流感病例以5岁及以下为主，发病率为每10万人537例(387-775)。5岁以下儿童大流行前、大流行初期和大流行后的年发病率分别为474/10万、452/10万和387/10万。与季节性流感病例相比，患有甲型H1N1流感pdm09的儿童年龄较大，就诊时间较早，出现严重症状的频率较低，与病毒合并感染的频率也较低。在越南中部的儿童ARI病例中，与季节性流感相比，A(H1N1)pdm09没有增加流感的年度住院发病率或疾病严重程度。
Influenza virus is one of the major viral pathogens causing pediatric acute respiratory infection (ARI). The spread of pandemic influenza A (A(H1N1)pdm09) in 2009 around the globe had a huge impact on global health. To investigate the impact of A(H1N1)pdm09 on pediatric ARI in Vietnam. An ongoing population-based prospective surveillance in central Vietnam was used. All children aged <15 years residing in Nha Trang city, enrolled to the ARI surveillance in Khanh Hoa General Hospital, from February 2007 through March 2011 were studied. Clinical data and nasopharyngeal swab samples were collected. Influenza A was detected and genotyped by multiplex polymerase chain reaction assays and sequencing. Among enrolled 2736 hospitalized ARI cases, 354 (13%) were positive for influenza A. Genotyping results revealed that seasonal H3N2 and H1N1 (sea-H1N1) viruses were cocirculating before A(H1N1)pdm09 appeared in July 2009. The A(H1N1)pdm09 replaced the sea-H1N1 after the pandemic. The majority of influenza A cases (90%) were aged <5 years with incidence rate of 537 (387–775) per 100 000 population. Annual incidence rates of hospitalized influenza cases for pre-, initial and post-pandemic periods among children aged <5 year were 474, 452, and 387 per 100 000, respectively. Children with A(H1N1)pdm09 were elder, visited the hospital earlier, less frequently had severe signs, and were less frequently associated with viral coinfection compared with seasonal influenza cases. The A(H1N1)pdm09 did not increase the influenza annual hospitalization incidence or disease severity compared with seasonal influenza among pediatric ARI cases in central Vietnam.
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影响因子：
3.7
作者：
Moorthy M;Samuel P;Peter JV;Vijayakumar S;Sekhar D;Verghese VP;Agarwal I;Moses PD;Ebenezer K;Abraham OC;Thomas K;Mathews P;Mishra AC;Lal R;Muliyil J;Abraham AM
通讯作者：
Abraham AM
影响因子：
3.7
作者：
Chuang JH;Huang AS;Huang WT;Liu MT;Chou JH;Chang FY;Chiu WT
通讯作者：
Chiu WT
DOI：
10.1371/currents.rrn1139
发表时间：
2009-12-20
期刊：
PLoS currents
影响因子：
--
作者：
Kamigaki T;Oshitani H
通讯作者：
Oshitani H
影响因子：
64.8
作者：
Everitt, Aaron R.;Clare, Simon;Pertel, Thomas;John, Sinu P.;Wash, Rachael S.;Smith, Sarah E.;Chin, Christopher R.;Feeley, Eric M.;Sims, Jennifer S.;Adams, David J.;Wise, Helen M.;Kane, Leanne;Goulding, David;Digard, Paul;Anttila, Verneri;Baillie, J. Kenneth;Walsh, Tim S.;Hume, David A.;Palotie, Aarno;Xue, Yali;Colonna, Vincenza;Tyler-Smith, Chris;Dunning, Jake;Gordon, Stephen B.;Smyth, Rosalind L.;Openshaw, Peter J.;Dougan, Gordon;Brass, Abraham L.;Kellam, Paul
通讯作者：
Kellam, Paul
影响因子：
11.8
作者：
Oshitani, Hitoshi;Kamigaki, Taro;Suzuki, Akira
通讯作者：
Suzuki, Akira