Estimation of the burden of pandemic(H1N1)2009 in developing countries: experience from a tertiary care center in South India.
Estimation of the burden of pandemic(H1N1)2009 in developing countries: experience from a tertiary care center in South India.
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DOI：
10.1371/journal.pone.0041507
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Abraham AM
中科院分区：
文献类型：
--
作者：
Moorthy M;Samuel P;Peter JV;Vijayakumar S;Sekhar D;Verghese VP;Agarwal I;Moses PD;Ebenezer K;Abraham OC;Thomas K;Mathews P;Mishra AC;Lal R;Muliyil J;Abraham AM
如果强制检测病毒来诊断感染，那么 2009 年 H1N1 流感大流行的负担可能会被低估。使用另一种方法，我们建议我们的机构经历了更高的流行病负担。前瞻性招募了一年内（2009 年 5 月至 2010 年 4 月）因流感样疾病 (ILI) 或严重急性呼吸道感染 (SARI) 就诊的连续患者 (n = 2588)，并通过实时 RT-PCR 进行甲型流感检测。每周趋势分析显示，与大流行前相比，在大流行高峰期出现 ILI/SARI 的患者增加了 11 倍，与大流行前 (7±2.5) 和大流行后 (5±3.8) 相比，大流行期间 SARI 入院人数显着 (P<0.001) 增加 (30±15.9 人/周)。然而，只有不到三分之一的 ILI/SARI 患者检测到甲型流感 [699 (27.0%)]；其中大部分（557/699，79.7%）是 2009 年 (H1N1) 大流行病毒 [A/H1N1/09]。 A/H1N1/09 阳性检测与出现前症状持续时间较短相关 (p = 0.03)。与 SARI 相比，更多 ILI 病例 A/H1N1/09 检测呈阳性（27.4% vs. 14.6%，P = 0.037）。当考虑到整个研究人群时，A/H1N1/09 阳性与较低的住院风险 (p<0.0001) 和 ICU 入住风险 (p = 0.013) 相关，表明大多数人患有轻度自限性疾病。对 ILI/SARI 每周趋势的分析表明，A/H1N1/09 造成的大流行负担比仅通过阳性 PCR 检测评估的估计值更高。该研究强调了使用基于医院的数据估计发展中国家大流行性流感负担的方法学考虑，这可能有助于评估未来呼吸道疾病爆发的影响。
The burden of the pandemic (H1N1) 2009 influenza might be underestimated if detection of the virus is mandated to diagnose infection. Using an alternate approach, we propose that a much higher pandemic burden was experienced in our institution. Consecutive patients (n = 2588) presenting to our hospital with influenza like illness (ILI) or severe acute respiratory infection (SARI) during a 1-year period (May 2009–April 2010) were prospectively recruited and tested for influenza A by real-time RT-PCR. Analysis of weekly trends showed an 11-fold increase in patients presenting with ILI/SARI during the peak pandemic period when compared with the pre-pandemic period and a significant (P<0.001) increase in SARI admissions during the pandemic period (30±15.9 admissions/week) when compared with pre-pandemic (7±2.5) and post-pandemic periods (5±3.8). However, Influenza A was detected in less than one-third of patients with ILI/SARI [699 (27.0%)]; a majority of these (557/699, 79.7%) were Pandemic (H1N1)2009 virus [A/H1N1/09]. An A/H1N1/09 positive test was correlated with shorter symptom duration prior to presentation (p = 0.03). More ILI cases tested positive for A/H1N1/09 when compared with SARI (27.4% vs. 14.6%, P = 0.037). When the entire study population was considered, A/H1N1/09 positivity was associated with lower risk of hospitalization (p<0.0001) and ICU admission (p = 0.013) suggesting mild self-limiting illness in a majority. Analysis of weekly trends of ILI/SARI suggest a higher burden of the pandemic attributable to A/H1N1/09 than estimates assessed by a positive PCR test alone. The study highlights methodological consideration in the estimation of burden of pandemic influenza in developing countries using hospital-based data that may help assess the impact of future outbreaks of respiratory illnesses.
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影响因子：
15.8
作者：
Van Kerkhove MD;Vandemaele KA;Shinde V;Jaramillo-Gutierrez G;Koukounari A;Donnelly CA;Carlino LO;Owen R;Paterson B;Pelletier L;Vachon J;Gonzalez C;Hongjie Y;Zijian F;Chuang SK;Au A;Buda S;Krause G;Haas W;Bonmarin I;Taniguichi K;Nakajima K;Shobayashi T;Takayama Y;Sunagawa T;Heraud JM;Orelle A;Palacios E;van der Sande MA;Wielders CC;Hunt D;Cutter J;Lee VJ;Thomas J;Santa-Olalla P;Sierra-Moros MJ;Hanshaoworakul W;Ungchusak K;Pebody R;Jain S;Mounts AW;WHO Working Group for Risk Factors for Severe H1N1pdm Infection
通讯作者：
WHO Working Group for Risk Factors for Severe H1N1pdm Infection
影响因子：
9.4
作者：
Shu, Bo;Wu, Kai-Hui;Lindstrom, Stephen
通讯作者：
Lindstrom, Stephen
影响因子：
14.6
作者：
Helferty, Melissa;Vachon, Julie;Pelletier, Louise
通讯作者：
Pelletier, Louise
影响因子：
3.7
作者：
Tandale BV;Pawar SD;Gurav YK;Chadha MS;Koratkar SS;Shelke VN;Mishra AC
通讯作者：
Mishra AC
DOI：
10.1126/science.1177127
发表时间：
2009-07-24
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Munster VJ;de Wit E;van den Brand JM;Herfst S;Schrauwen EJ;Bestebroer TM;van de Vijver D;Boucher CA;Koopmans M;Rimmelzwaan GF;Kuiken T;Osterhaus AD;Fouchier RA
通讯作者：
Fouchier RA