Increased Frequency of Myeloid-Derived Suppressor Cells in Myasthenia Gravis After Immunotherapy.
Increased Frequency of Myeloid-Derived Suppressor Cells in Myasthenia Gravis After Immunotherapy.
复制标题
免疫治疗后重症肌无力中骨髓源性抑制细胞的频率增加
DOI：
10.3389/fneur.2022.902384
复制
发表时间：
2022
影响因子：
3.4
通讯作者：
中科院分区：
文献类型：
--
作者：
髓源性抑制细胞（MDSCs）是一类具有免疫调节功能的髓系祖细胞，其在重症肌无力（MG）中的作用尚不清楚。在这项研究中，我们研究了免疫治疗前后MG中MDSCs的表型和功能改变。免疫治疗后，MDSCs的频率显著增加，并与Th1或Th17细胞的频率呈负相关。未经治疗的MG患者的MDSCs显示t细胞中IFN-γ产生的抑制受损，免疫治疗后发现免疫抑制功能改善。免疫治疗后，MDSCs中Arg-1的MFI也增加。这些发现提示免疫治疗前后MDSCs的功能差异，MDSCs可能在疾病缓解中发挥作用。
Myeloid-derived suppressor cells (MDSCs) are a population of myeloid progenitor cells with immunoregulatory functions and their role in myasthenia gravis (MG) was unknown. In this study, we investigated the phenotypic and functional alterations of MDSCs in MG before and after immunotherapy. The frequency of MDSCs significantly increased and negatively correlated to that of Th1 or Th17 cells after immunotherapy. MDSCs from untreated patients with MG showed an impaired suppression of IFN-γ production in T-cells and improved immunosuppressive function was identified after immunotherapy. The MFI of Arg-1 in MDSCs also increased after immunotherapy. These findings suggested the functional difference in MDSCs before and after immunotherapy, and MDSCs might play a role in disease remission.
登录
查看更多内容
DOI：
10.1016/j.tvjl.2020.105581
发表时间：
2021-01
期刊：
Veterinary journal (London, England : 1997)
影响因子：
--
作者：
Wu Y;Chang YM;Lawson BS;Galban EM;Mittelman NS;Benedicenti L;Petesch SC;Carroll AB;Punt JA;Luo J;Garden OA
通讯作者：
Garden OA
影响因子：
20.3
作者：
Jitschin, Regina;Braun, Martina;Mougiakakos, Dimitrios
通讯作者：
Mougiakakos, Dimitrios
高剂量地塞米松通过 Ets1 纠正免疫性血小板减少症中受损的骨髓源性抑制细胞功能
影响因子：
20.3
作者：
Hou, Yu;Feng, Qi;Peng, Jun
通讯作者：
Peng, Jun
影响因子：
4.4
作者：
Huang, Ang;Zhang, Bo;Guo, YaJun
通讯作者：
Guo, YaJun
影响因子：
16.6
作者：
Bronte V;Brandau S;Chen SH;Colombo MP;Frey AB;Greten TF;Mandruzzato S;Murray PJ;Ochoa A;Ostrand-Rosenberg S;Rodriguez PC;Sica A;Umansky V;Vonderheide RH;Gabrilovich DI
通讯作者：
Gabrilovich DI