Myeloid-derived suppressor cell and regulatory T cell frequencies in canine myasthenia gravis: A pilot study.
Myeloid-derived suppressor cell and regulatory T cell frequencies in canine myasthenia gravis: A pilot study.
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DOI：
10.1016/j.tvjl.2020.105581
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发表时间：
2021-01
期刊：
影响因子：
--
通讯作者：
Garden OA
中科院分区：
文献类型：
--
作者：
Wu Y;Chang YM;Lawson BS;Galban EM;Mittelman NS;Benedicenti L;Petesch SC;Carroll AB;Punt JA;Luo J;Garden OA
重症肌无力（MG）是一种T细胞依赖性、B细胞介导的自身免疫性疾病。关于其在犬中的细胞发病机制知之甚少。本研究首次初步评估了血清阳性全身性MG犬外周血中髓源性抑制细胞（MDSC）和调节性T细胞（T细胞）的频率。与诊断为MG以外的血清阴性犬或健康犬相比，未观察到MG犬MDSC或TcB频率发生变化。在三只MG犬中进行的纵向研究显示，两个群体的相对数量与疾病的临床病程之间没有相关性。MG犬中MDSC和Treg的频率均未显示与抗AChR抗体滴度相关。这些发现表明，在MG中不发生免疫抑制人群的频率畸变，但它们需要在大规模的前瞻性研究中得到验证。
Myasthenia gravis (MG) is a T cell-dependent, B cell-mediated autoimmune disease. Little is known about its cellular pathogenesis in dogs. This study provides the first preliminary assessment of the frequency of myeloid-derived suppressor cells (MDSCs) and regulatory T cells (Tregs) in the peripheral blood of dogs with seropositive generalized MG. No alteration in frequency of either MDSCs or Tregs in dogs with MG was observed when compared to those in either seronegative dogs with diagnoses other than MG, or healthy dogs. A longitudinal study in three dogs with MG revealed no correlation between the relative numbers of either population and the clinical course of disease. Neither the frequency of MDSCs nor of Tregs showed a correlation with anti-AChR antibody titer in dogs with MG. These findings suggest that aberrations in the frequency of either immunosuppressive population do not occur in MG, but they need to be validated in large-scale prospective studies.
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影响因子：
10.1
作者：
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通讯作者：
Gabrilovich DI
影响因子：
7.3
作者：
Schmidt SV;Nino-Castro AC;Schultze JL
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Schultze JL
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影响因子：
4.4
作者：
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通讯作者：
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