Longitudinal hippocampal atrophy in hippocampal sclerosis of aging.
Longitudinal hippocampal atrophy in hippocampal sclerosis of aging.
复制标题
老年性海马区硬化症的海马区纵向萎缩。
DOI：
10.1016/j.nbas.2023.100092
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Sajjadi, S. Ahmad
中科院分区：
文献类型：
--
作者：
Li, Janice X.;Nguyen, Hannah L.;Qian, Tianchen;Woodworth, Davis C.;Sajjadi, S. Ahmad
老年性海马硬化症（HS-A）是老年人中常见的退行性神经病理学，与痴呆有关。HS-A的特点是尸检时海马萎缩不成比例，但不能在生活中诊断。因此，对HS-A患者海马萎缩的发生和进展知之甚少。为了更好地了解HS-A患者海马萎缩的发生和进展，我们在尸检时使用系列MRI检查了HS-A患者的纵向海马萎缩（HS-A+，n = 8）与无HS-A的边缘优势年龄相关TDP-43脑病神经病理学改变（LATE-NC）的参与者（n = 13）相比，无HS-A或LATE-NC的阿尔茨海默病神经病理学改变（ADNC）（n = 16），以及无这些病理的那些（n = 7）。我们发现，与其他组相比，HS-A参与者的海马体积较低，并且这种萎缩先于痴呆症的发作。还有一些证据表明，HS-A患者海马体积损失的速度略慢。总之，这些结果表明HS-A中观察到的不成比例的海马萎缩可能在痴呆之前开始。
Hippocampal sclerosis of aging (HS-A) is a common degenerative neuropathology in older individuals and is associated with dementia. HS-A is characterized by disproportionate hippocampal atrophy at autopsy but cannot be diagnosed during life. Therefore, little is known about the onset and progression of hippocampal atrophy in individuals with HS-A. To better understand the onset and progression of hippocampal atrophy in HS-A, we examined longitudinal hippocampal atrophy using serial MRI in participants with HS-A at autopsy (HS-A+, n = 8) compared to participants with limbic-predominant age-related TDP-43 encephalopathy neuropathological change (LATE-NC) without HS-A (n = 13), Alzheimer’s disease neuropathologic change (ADNC) without HS-A or LATE-NC (n = 16), and those without these pathologies (n = 7). We found that participants with HS-A had lower hippocampal volumes compared to the other groups, and this atrophy preceded the onset of dementia. There was also some evidence that rates of hippocampal volume loss were slightly slower in those with HS-A. Together, these results suggest that the disproportionate hippocampal atrophy seen in HS-A may begin early prior to dementia.
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