Maternal uterine vascular remodeling during pregnancy.

Maternal uterine vascular remodeling during pregnancy.
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DOI:
10.1152/physiol.00033.2008
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发表时间:
2009-02
期刊:
Physiology (Bethesda, Md.)
影响因子:
--
通讯作者:
Mandala M
Mandala M
中科院分区:
其他
文献类型:
--
作者:
Osol G;Mandala M

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充足的子宫胎盘血流量对于正常妊娠结局至关重要,是通过整个子宫循环的协调生长和重塑以及新的胎儿血管器官:胎盘的形成来实现的。重塑过程涉及许多细胞过程,包括增生和肥大、现有元素的重新排列以及细胞外基质的变化。在这篇综述中,我们提供了有关妊娠期间子宫血流量增加的信息,胎盘类型对子宫血管阻力分布的影响,妊娠期间母体子宫血管重塑的模式、性质和程度的考虑,以及对潜在细胞机制的了解。
Sufficient uteroplacental blood flow is essential for normal pregnancy outcome and is accomplished by the coordinated growth and remodeling of the entire uterine circulation, as well as the creation of a new fetal vascular organ: the placenta. The process of remodeling involves a number of cellular processes, including hyperplasia and hypertrophy, rearrangement of existing elements, and changes in extracellular matrix. In this review, we provide information on uterine blood flow increases during pregnancy, the influence of placentation type on the distribution of uterine vascular resistance, consideration of the patterns, nature, and extent of maternal uterine vascular remodeling during pregnancy, and what is known about the underlying cellular mechanisms.
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