Mammary growth hormone and tumorigenesis--lessons from the dog.
Mammary growth hormone and tumorigenesis--lessons from the dog.
复制标题
乳腺生长激素和肿瘤发生——来自狗的教训。
作者：
J. Mol;I. S. Leeuwen;E. Garderen;P. Selman;M. A. Oosterlaken;J. Schalken;A. Rijnberk
20世纪90年代初，孕激素诱导的犬生长激素（GH）过量起源于乳腺，这一发现可被视为犬乳腺癌发病机制研究的标志。GH的局部生物合成和释放可能在乳腺中提供高度增殖的环境，这有助于乳腺肿瘤的发生和/或进展。在最终的目标，如预防肿瘤形成或抑制肿瘤的促进，可以实现它是非常重要的，以阐明的机制，炔雌醇诱导乳腺生长激素的生产和局部自分泌/旁分泌作用的GH的机制。这些局部GH作用可通过GH的直接生长刺激作用以及刺激胰岛素样生长因子-I（IGF-I）生物合成介导的间接作用来实现。IGF的生物学效应很大程度上取决于IGF结合蛋白（IGFBPs）的存在，IGFBPs可以增强或抑制IGF的活性。本文综述了近年来对局部乳腺GH-IGF轴的研究进展，以及对犬乳腺癌研究的启示。
The discovery in the early 1990s that progestin-induced growth hormone (GH) excess in the dog originates in the mammary gland can be seen as a hallmark in the research on the pathogenesis of mammary cancer in the dog. The local biosynthesis and release of GH may provide a highly proliferative environment in the mammary gland, which contributes to the development and/or progression of mammary tumours. Before final goals such as prevention of tumour formation or inhibition of tumour promotion can be achieved it is of eminent importance to elucidate the mechanism of progesterone-induced mammary GH production and the mechanism of local autocrine/paracrine action of GH. These local GH effects may be achieved through direct growth stimulating effects of GH as well as by indirect effects mediated by the stimulation of the biosynthesis of insulin-like growth factor-I (IGF-I). The biological effects of the IGFs largely depend on the presence of IGF binding proteins (IGFBPs) which may both enhance or inhibit the activity of the IGFs. This review concentrates on recent advances in the understanding of the local mammary GH-IGF axis and the lessons which can be drawn from the dog for mammary cancer research in other species.
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人类生长激素变体是一种具有生物活性的生长激素和催乳激素。
影响因子：
4.8
作者：
MacLeod,JN;Worsley,I;Ray,J;Friesen,HG;Liebhaber,SA;Cooke,NE
通讯作者：
Cooke,NE
影响因子：
20.3
作者：
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通讯作者：
John I. Jones;D. Clemmons
大鼠卵巢胰岛素样生长因子结合蛋白 5 内肽酶的表征和激素调节：一种 FSH 诱导的颗粒细胞衍生的金属蛋白酶。
DOI：
10.1210/endo.139.3.5845
发表时间：
1998
期刊：
Endocrinology.
影响因子：
--
作者：
Resnick,CE;Fielder,PJ;Rosenfeld,RG;Adashi,EY
通讯作者：
Adashi,EY
影响因子：
5.5
作者：
PIKE, MC;SPICER, DV;PRESS, MF
通讯作者：
PRESS, MF
DOI：
10.1073/pnas.95.2.696
发表时间：
1998-01-20
影响因子：
11.1
作者：
Shyamala, G;Yang, X;Dale, E
通讯作者：
Dale, E