A small secreted protein NICOL regulates lumicrine-mediated sperm maturation and male fertility.
A small secreted protein NICOL regulates lumicrine-mediated sperm maturation and male fertility.
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DOI：
10.1038/s41467-023-37984-x
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发表时间：
2023-04-24
影响因子：
16.6
通讯作者：
Ikawa, Masahito
中科院分区：
文献类型：
--
作者：
Kiyozumi, Daiji;Shimada, Kentaro;Chalick, Michael;Emori, Chihiro;Kodani, Mayo;Oura, Seiya;Noda, Taichi;Endo, Tsutomu;Matzuk, Martin M.;Wreschner, Daniel H.;Ikawa, Masahito
The mammalian spermatozoa produced in the testis require functional maturation in the epididymis for their full competence. Epididymal sperm maturation is regulated by lumicrine signalling pathways in which testis-derived secreted signals relocate to the epididymis lumen and promote functional differentiation. However, the detailed mechanisms of lumicrine regulation are unclear. Herein, we demonstrate that a small secreted protein, NELL2-interacting cofactor for lumicrine signalling (NICOL), plays a crucial role in lumicrine signalling in mice. NICOL is expressed in male reproductive organs, including the testis, and forms a complex with the testis-secreted protein NELL2, which is transported transluminally from the testis to the epididymis. Males lacking Nicol are sterile due to impaired NELL2-mediated lumicrine signalling, leading to defective epididymal differentiation and deficient sperm maturation but can be restored by NICOL expression in testicular germ cells. Our results demonstrate how lumicrine signalling regulates epididymal function for successful sperm maturation and male fertility. Mammalian sperm need to be matured in the epididymis to achieve potential for fertility. Here the authors identify NICOL as a secreted protein that acts on the epididymis to trigger its functional differentiation and induce sperm maturation.
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影响因子：
--
作者：
BEDFORD, JM
通讯作者：
BEDFORD, JM
DOI：
10.1073/pnas.1635054100
发表时间：
2003-10-14
影响因子：
11.1
作者：
Schultz, N;Hamra, FK;Garbers, DL
通讯作者：
Garbers, DL
影响因子：
2.7
作者：
Nishimura, H;Cho, C;Primakoff, P
通讯作者：
Primakoff, P
影响因子：
105.7
作者：
HULL, MGR;GLAZENER, CMA;DESAI, KM
通讯作者：
DESAI, KM
DOI：
10.1038/s41571-020-0408-9
发表时间：
2021-01
期刊：
Nature reviews. Clinical oncology
影响因子：
--
作者：
Drilon A;Jenkins C;Iyer S;Schoenfeld A;Keddy C;Davare MA
通讯作者：
Davare MA