NMDA receptors are not required for pattern completion during associative memory recall.
NMDA receptors are not required for pattern completion during associative memory recall.
复制标题
联想记忆回忆期间，模式完成不需要 NMDA 受体
DOI：
10.1371/journal.pone.0019326
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发表时间：
2011-04-29
期刊：
影响因子：
3.7
通讯作者：
Tsien JZ
中科院分区：
文献类型：
--
作者：
Mei B;Li F;Gu Y;Cui Z;Tsien JZ
模式补全（Pattern Completion）是一种由外部线索子集引发的完整记忆的提取能力，是许多计算模型的主要关注点。先前的一项研究报告说，这种模式的完成需要海马体中的NMDA受体。然而，这种说法是来自一个非诱导性基因敲除实验，其中NMDA受体在整个记忆过程的所有阶段以及动物的成年生活中都不存在。这提出了一个关键问题，即之前描述的结果是否真正是由于提取中需要NMDA受体而产生的。在这里，我们已经研究了NMDA受体的作用，通过诱导敲除NMDA受体的记忆检索阶段有限的模式完成。通过使用两个独立的小鼠系，我们发现，诱导基因敲除小鼠，缺乏NMDA受体在前脑或海马CA1区的记忆检索时，表现出正常的回忆联想空间参考记忆，无论检索发生在全线索或部分线索条件下。此外，在保持测试中，NMDA受体的系统拮抗剂也没有影响空间水迷宫记忆的完全线索或部分线索回忆。因此，遗传学和药理学实验共同表明，空间联想记忆回忆过程中的模式完成不需要海马或前脑中的NMDA受体。
Pattern completion, the ability to retrieve complete memories initiated by subsets of external cues, has been a major focus of many computation models. A previously study reports that such pattern completion requires NMDA receptors in the hippocampus. However, such a claim was derived from a non-inducible gene knockout experiment in which the NMDA receptors were absent throughout all stages of memory processes as well as animal's adult life. This raises the critical question regarding whether the previously described results were truly resulting from the requirement of the NMDA receptors in retrieval. Here, we have examined the role of the NMDA receptors in pattern completion via inducible knockout of NMDA receptors limited to the memory retrieval stage. By using two independent mouse lines, we found that inducible knockout mice, lacking NMDA receptor in either forebrain or hippocampus CA1 region at the time of memory retrieval, exhibited normal recall of associative spatial reference memory regardless of whether retrievals took place under full-cue or partial-cue conditions. Moreover, systemic antagonism of NMDA receptor during retention tests also had no effect on full-cue or partial-cue recall of spatial water maze memories. Thus, both genetic and pharmacological experiments collectively demonstrate that pattern completion during spatial associative memory recall does not require the NMDA receptor in the hippocampus or forebrain.
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影响因子：
3.3
作者：
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通讯作者：
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影响因子：
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