Voxel-based assessment of gray and white matter volumes in Alzheimer's disease.
Voxel-based assessment of gray and white matter volumes in Alzheimer's disease.
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DOI：
10.1016/j.neulet.2009.10.086
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发表时间：
2010-01-04
影响因子：
2.5
通讯作者：
Chen K
中科院分区：
文献类型：
--
作者：
Guo X;Wang Z;Li K;Li Z;Qi Z;Jin Z;Yao L;Chen K
使用特定于研究的模板和优化的基于体素的形态计量学(VBM)，这项研究调查了13名阿尔茨海默病(AD)患者和14名年龄和性别匹配的正常对照组的灰质和白质的异常，以提供对同时发生的结构变化的描述。与以往的研究一致，AD患者的灰质体积显著减少，主要分布在海马区、海马旁回、岛叶、颞上/中回、丘脑、扣带回和顶上/下小叶。此外，白质体积减少主要见于颞叶、穹窿体部和下纵束。此外，一些额外的白质区域，如中央前回、扣带回、额上回、额下回和顶叶回下回也受到影响。灰质和白质体积减少的模式有助于我们了解AD的潜在病理机制，并有可能作为未来AD研究的影像标志物。
Using the study-specific templates and optimized voxel-based morphometry (VBM), this study investigated abnormalities in gray and white matter to provide depiction of the concurrent structural changes in 13 patients with Alzheimer’s disease (AD) compared with 14 age- and sex-matched normal controls. Consistent with previous studies, patients with AD exhibited significant gray matter volume reductions mainly in the hippocampus, parahippocampal gyrus, insula, superior/middle temporal gyrus, thalamus, cingulate gyrus, and superior/inferior parietal lobule. In addition, white matter volume reductions were found predominately in the temporal lobe, corpus callosum, and inferior longitudinal fasciculus. Furthermore, a number of additional white matter regions such as precentral gyrus, cingulate fasciculus, superior and inferior frontal gyrus, and sub-gyral in parietal lobe were also affected. The pattern of gray and white matter volume reductions helps us understand the underlying pathologic mechanisms in AD and potentially can be used as an imaging marker for the studies of AD in the future.
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影响因子：
9.9
作者：
SCHELTENS, P;BARKHOF, F;KAMPHORST, W
通讯作者：
KAMPHORST, W
DOI：
10.1073/pnas.0603414103
发表时间：
2006-06-27
影响因子：
11.1
作者：
Stoub, Travis R.;deToledo-Morrell, Leyla;Shah, Raj C.
通讯作者：
Shah, Raj C.
影响因子：
--
作者：
Teipel, SJ;Bayer, W;Hampel, H
通讯作者：
Hampel, H
影响因子：
5.7
作者：
Chételat, G;Landeau, B;Baron, JC
通讯作者：
Baron, JC
影响因子：
2.3
作者：
Pantel, J;Schröder, J;Knopp, MV
通讯作者：
Knopp, MV