Sex differences in the association of the apolipoprotein E epsilon 4 allele with incidence of dementia, cognitive impairment, and decline.
Sex differences in the association of the apolipoprotein E epsilon 4 allele with incidence of dementia, cognitive impairment, and decline.
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DOI：
10.1016/j.neurobiolaging.2010.05.017
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发表时间：
2012-04
影响因子：
4.2
通讯作者：
Zonderman AB
中科院分区：
文献类型：
--
作者：
Beydoun MA;Boueiz A;Abougergi MS;Kitner-Triolo MH;Beydoun HA;Resnick SM;O'Brien R;Zonderman AB
我们研究了ApoE4+状态与几种认知结果之间的纵向关联，并测试了性别对效果的影响。来自巴尔的摩老龄化纵向研究（BLSA）的644名非西班牙裔白人成年人的数据被使用。对痴呆发病、认知障碍和衰退进行纵向评估。在平均27.5年的随访后，113名参与者患上了痴呆症。ApoE4+预测痴呆有显著性差异（HR=2.89; 95% CI: 1.93 ~ 4.33），性别差异不显著。在预测认知的所有时间点上，ApoE4+状态与加州语言学习测试（cvlt延迟回忆和列表A总回忆）和语言流畅性测试类别的损害或下降之间的正相关显著强于男性。这种ApoE4×sex交互作用仅在cvlt延迟回忆的bonferroni校正中保持显著。以痴呆前的时间点进行认知预测，在女性中，尽管只有在bonferroni校正之前，但cvlt延迟回忆的损害与ApoE4+状态之间的正相关仍然更强。虽然ApoE4+状态似乎是痴呆症的性别中立风险因素，但它与言语记忆和学习能力下降和障碍的关联在女性中更强。
We examined longitudinal associations between ApoE4+ status and several cognitive outcomes and tested effect modification by sex. Data on 644 Non-Hispanic White adults, from the Baltimore Longitudinal Study of Aging (BLSA) were used. Dementia onset, cognitive impairment and decline were assessed longitudinally. After 27.5 years median follow-up, 113 participants developed dementia. ApoE4+ predicted dementia significantly (HR=2.89; 95% CI: 1.93–4.33), with non-significant sex differences. Taking all time points for predicting cognition, women had significantly stronger positive associations than men between ApoE4+ status and impairment or decline on the California Verbal Learning Test (CVLT-delayed recall and List A total recall) and on Verbal Fluency Test-Categories. This ApoE4×sex interaction remained significant with bonferroni correction only for CVLT-delayed recall. Taking time points prior to dementia for cognitive predictions, the positive association between impairment in CVLT-delayed recall and ApoE4+ status remained stronger among women, though only before bonferroni correction. While ApoE4+ status appears to be a sex neutral risk factor for dementia, its association with verbal memory and learning decline and impairment was stronger among women.
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影响因子：
0.8
作者：
Aggarwal, NT;Wilson, RS;Bennett, DA
通讯作者：
Bennett, DA
影响因子：
9.9
作者：
Bretsky, P;Guralnik, JM;Seeman, TE
通讯作者：
Seeman, TE
影响因子：
--
作者：
FESKENS, EJM;HAVEKES, LM;KROMHOUT, D
通讯作者：
KROMHOUT, D
影响因子：
7.1
作者：
Beydoun, May A.;Kuczmarski, Marie T. Fanelli;Zonderman, Alan B.
通讯作者：
Zonderman, Alan B.
影响因子：
2.5
作者：
Berr, C;Dufouil, C;Alperovitch, A
通讯作者：
Alperovitch, A