Abnormality of glycometabolism related factors in non-psychotic offspring of schizophrenic patients
Abnormality of glycometabolism related factors in non-psychotic offspring of schizophrenic patients
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精神分裂症患者非精神病子代糖代谢相关因素异常
DOI：
10.1016/j.psychres.2011.12.014
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发表时间：
2012-07
影响因子：
11.3
通讯作者：
杨建立
中科院分区：
文献类型：
--
作者：
杨建立
精神分裂症患者的糖代谢异常率似乎较高。有人认为这些可能继发于使用抗精神病药物。然而，研究结果表明，异常的葡萄糖代谢可能与精神分裂症的发病机制有关。本研究检查了精神分裂症患者健康后代的糖代谢相关因子的空腹血浆水平。我们的目的是检验葡萄糖代谢异常可能与精神分裂症发病机制有关的假设。招募了 32 名符合 DSM-IV 精神分裂症标准的精神分裂症住院患者的健康后代和 37 名对照受试者。所有受试者均检测了空腹血浆葡萄糖、胰岛素、胰岛素样生长因子 1 (IGF-1)、生长激素 (GH)、瘦素和皮质醇水平。与对照组相比，精神分裂症患者的后代平均血浆胰岛素和胰岛素抵抗显着升高，平均血浆IGF-1水平显着降低。同时，精神分裂症患者的后代和健康对照受试者的平均空腹血浆葡萄糖、生长激素、瘦素和皮质醇水平没有显着差异。精神分裂症患者的后代在糖代谢相关因素方面与对照对象存在显着差异。葡萄糖代谢异常可能与精神分裂症的发病机制有关。
Schizophrenic patients appear to have higher rates of abnormality of glycometabolism. It has been suggested that these could be secondary to the use of antipsychotics. However, findings indicate that abnormal glucose metabolism may be potentially involved in the pathogenesis of schizophrenia. The present study examined the fasting plasma levels of glycometabolism related factors in healthy offspring of schizophrenic patients. Our objective was to test the hypothesis that abnormal glucose metabolism might be potentially involved in the pathogenesis of schizophrenia. Thirty-two healthy offspring of schizophrenic inpatients who met DSM-IV criteria for schizophrenia and 37 comparison subjects were recruited. Fasting plasma levels of glucose, insulin, insulin-like growth factor 1 (IGF-1), growth hormone (GH), leptin and cortisol were tested for all subjects. Compared with controls, offspring of schizophrenic patients had significantly higher mean plasma insulin and insulin resistance, and lower mean plasma IGF-1 level. Meanwhile, the mean fasting plasma levels of glucose, GH, leptin and cortisol did not differ significantly between offspring of schizophrenic patients and healthy comparison subjects. Offspring of schizophrenic patients showed significant differences from comparison subjects in glycometabolism related factors. Abnormal glucose metabolism might be potentially involved in the pathogenesis of schizophrenia.
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影响因子：
4.8
作者：
L. Mathews;R. Hammer;R. Brinster;R. Palmiter
通讯作者：
L. Mathews;R. Hammer;R. Brinster;R. Palmiter
影响因子：
6.6
作者：
Dixon, L;Weiden, P;Lehman, A
通讯作者：
Lehman, A
DOI：
--
发表时间：
2001-01
期刊：
The Journal of clinical psychiatry
影响因子：
--
作者：
J. Lindenmayer;Ann-Marie Nathan;Robert C. Smith
通讯作者：
J. Lindenmayer;Ann-Marie Nathan;Robert C. Smith
DOI：
10.1001/archneurpsyc.1946.02300180084007
发表时间：
1946-01-01
影响因子：
--
作者：
FREEMAN, H
通讯作者：
FREEMAN, H
影响因子：
4.5
作者：
McEvoy, JP;Meyer, JM;Lieberman, JA
通讯作者：
Lieberman, JA