Glucocorticoid responsiveness of the transcriptional enhancer of Moloney Murine Sarcoma Virus
Glucocorticoid responsiveness of the transcriptional enhancer of Moloney Murine Sarcoma Virus
复制标题
莫洛尼鼠肉瘤病毒转录增强子的糖皮质激素反应
DOI：
10.1016/0092-8674(86)90745-2
复制
发表时间：
1986
期刊：
影响因子：
64.5
通讯作者：
G. Schütz
中科院分区：
文献类型：
--
作者：
R. Miksicek;A. Heber;W. Schmid;U. Danesch;G. Posseckert;M. Beato;G. Schütz
The long terminal repeat of Moloney Murine Sarcoma Virus (MoMSV) contains an imperfect direct repeat that serves as a strong transcriptional enhancer. The strength of the MoMSV enhancer is strongly dependent on the presence of glucocorticoid hormone. Mapping studies in combination with DNAase I footprinting experiments define the presence of glucocorticoid regulatory elements at the promoter-proximal ends of each enhancer repeat. These elements behave like inducible enhancers: their regulatory activity is independent of position and orientation when they are linked in cis to a heterologous promoter. These data demonstrate the modular nature of the MoMSV enhancer and identify the glucocorticoid receptor as one of the trans-acting factors that interact with the MoMSV enhancer and mediate its transcriptional activity.
鼠逆转录病毒长末端重复中的元件增强了胸苷激酶基因的稳定转化。
影响因子：
14.9
作者：
Jolly,DJ;Esty,AC;Subramani,S;Friedmann,T;Verma,IM
通讯作者：
Verma,IM
维斯纳病毒的顺式和反式转录调控。
DOI：
10.1126/science.2990051
发表时间：
1985
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Hess,JL;Clements,JE;Narayan,O
通讯作者：
Narayan,O
影响因子：
14.9
作者：
LOPATA, MA;CLEVELAND, DW;SOLLNERWEBB, B
通讯作者：
SOLLNERWEBB, B