Clinical characteristics of 41 patients with pneumonia due to 2019 novel coronavirus disease (COVID-19) in Jilin, China.
Clinical characteristics of 41 patients with pneumonia due to 2019 novel coronavirus disease (COVID-19) in Jilin, China.
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在中国吉林，2019年新型冠状病毒病（COVID-19）引起的41例肺炎患者的临床特征。
DOI：
10.1186/s12879-020-05677-1
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发表时间：
2020-12-17
影响因子：
3.7
通讯作者：
Du N
中科院分区：
文献类型：
--
作者：
Zhang Q;Xu Q;Chen YY;Lou LX;Che LH;Li XH;Sun LY;Bao WG;Du N
对吉林省新型冠状病毒病（COVID-19）确诊患者的临床特征进行调查。回顾性收集41例确诊COVID-19住院患者的临床、实验室、影像学和治疗资料。根据中国国家卫生和医疗委员会的指南，将人群按疾病严重程度分为轻度、中度和重度。本研究共纳入41例住院新冠肺炎患者，年龄中位数为45岁（四分位数区间[IQR] 31-53岁，范围10-87岁），女性18例（43.9%）。所有患者近期均曾到过武汉或其他地方（即北京、泰国）或有武汉相关暴露史。常见症状为发热32例（78%）、咳嗽29例（70.7%）。所有患者均无乙型/丙型肝炎。22例（53.7%）患者CRP （c -反应蛋白，11.3 mg/L[四分位数范围{IQR}， 2.45-35.2]）升高，41例（100%）患者心肌肌钙蛋白I （1.5 ng/mL [IQR, 0.8-5.0]）升高。胸部计算机断层扫描显示27例（65.9%）患者双侧磨玻璃影（GGO）或GGO伴肺实变。31例（75.6%）患者心电图异常。三组患者CRP、心肌肌钙蛋白I水平、双肺GGO分布、心电图变化比较，差异均有统计学意义（p < 0.05）。心肌肌钙蛋白I与CRP （r = 0.704, p = 0.042）、LDH （r = 0.738, p = 0.037）呈正相关。各组之间的显著差异表明，一些临床参数可能作为入院时COVID-19严重程度的生物标志物。cTnI升高可作为重症COVID-19的预测因子，反映重症COVID-19患者的预后。结果值得进一步检查和确认。
The clinical characteristics of patients with confirmed 2019 novel coronavirus disease (COVID-19) in Jilin Province, China were investigated. Clinical, laboratory, radiology, and treatment data of 41 hospitalized patients with confirmed COVID-19 were retrospectively collected. The population was stratified by disease severity as mild, moderate, or severe, based on guidelines of the National Health and Medical Commission of China. The 41 hospitalized patients with COVID-19 were studied, and the median age was 45 years (interquartile range [IQR], 31–53; range, 10–87 years) and 18 patients (43.9%) were female. All of the patients had recently visited Wuhan or other places (ie, Beijing, Thailand) or had Wuhan-related exposure. Common symptoms included fever (32[78%]) and cough (29[70.7%]). All patients were without hepatitis B/C virus hepatitis. CRP (C-reactive protein, 11.3 mg/L [interquartile range {IQR}, 2.45–35.2]) was elevated in 22 patients (53.7%), and cardiac troponin I (1.5 ng/mL [IQR, 0.8–5.0]) was elevated in 41 patients (100%). Chest computed tomographic scans showed bilateral ground glass opacity (GGO) or GGO with consolidation in the lungs of 27(65.9%) patients. 31(75.6%) patients had an abnormal electrocardiograph (ECG). Comparing the three groups, the levels of CRP and cardiac troponin I, GGO distribution in bilateral lungs, and electrocardiogram changes were statistically significant (p < 0.05). Cardiac troponin I had a strong positive correlation with CRP (r = 0.704, p = 0.042) and LDH (r = 0.738, p = 0.037). Significant differences among the groups suggest that several clinical parameters may serve as biomarkers of COVID-19 severity at hospital admission. Elevated cTnI could be considered as a predictor of severe COVID-19, reflecting the prognosis of patients with severe COVID-19. The results warrant further inspection and confirmation.
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影响因子：
168.9
作者：
Huang, Chaolin;Wang, Yeming;Cao, Bin
通讯作者：
Cao, Bin
影响因子：
168.9
作者：
Chan, Jasper Fuk-Woo;Yuan, Shuofeng;Yuen, Kwok-Yung
通讯作者：
Yuen, Kwok-Yung
影响因子：
5.2
作者：
Han, Yi;Zhang, Haidong;Gu, Guorong
通讯作者：
Gu, Guorong
影响因子：
4.6
作者：
Lupia, Tommaso;Scabini, Silvia;Corcione, Silvia
通讯作者：
Corcione, Silvia
影响因子：
7.3
作者：
Hamming, I;Timens, W;van Goor, H
通讯作者：
van Goor, H