Clinical management of Staphylococcus aureus bacteremia: a review.

Clinical management of Staphylococcus aureus bacteremia: a review.
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金黄色葡萄球菌菌血症的临床管理:评论。

DOI:
10.1001/jama.2014.9743
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发表时间:
2014-10-01
影响因子:
120.7
通讯作者:
Fowler, Vance G., Jr.
Fowler, Vance G., Jr.
中科院分区:
医学1区
文献类型:
--
作者:
Holland, Thomas L.;Arnold, Christopher;Fowler, Vance G., Jr.

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几种治疗策略可以改善金黄色葡萄球菌菌血症 (SAB) 患者的预后。然而,支持这些管理策略的证据强度差异很大。对涉及 SAB 管理策略的两个未解决问题的证据进行系统回顾:1)所有 SAB 病例都需要经食管超声心动图(TEE); 2) 治疗耐甲氧西林金黄色葡萄球菌 (MRSA) 菌血症的最佳抗生素疗法是什么?从一开始到 2014 年 5 月,我们进行了一项 PubMed 搜索,以寻找解决 TEE 在 SAB 中的作用的研究。 1990 年 1 月 1 日至 2014 年 5 月 28 日对 PubMed、EMBASE 和 Cochrane 图书馆进行了第二次检索,以查找针对 MRSA 菌血症的抗生素治疗的研究。报告了 MRSA 菌血症全身抗生素治疗结果的研究也被纳入其中。所有检索均通过对纳入研究的参考书目进行审查而得到增强。证据质量通过至少两名作者独立评估的共识,使用 GRADE 系统进行评估。在总共 3513 名患者的 9 项研究中,与 TTE (2-14%) 相比,使用 TEE 与更高的心内膜炎诊断率 (14-25%) 相关。五项研究提出了确定可以安全避免 TEE 的患者的标准。在考虑的 83 项研究中,仅确定了一项针对 MRSA 菌血症的抗生素治疗的高质量试验。大多数 SAB 当代管理策略都是基于低质量的证据。 TEE 适用于大多数 SAB 患者。或许可以确定一部分可以安全避免 TEE 的 SAB 患者。万古霉素和达托霉素是治疗 MRSA 菌血症的一线抗生素选择。迫切需要精心设计的研究来解决 SAB 的管理问题。
Several management strategies may improve outcomes in patients with Staphylococcus aureus bacteremia (SAB). The strength of evidence supporting these management strategies, however, varies widely. To perform a systematic review of the evidence for two unresolved questions involving management strategies for SAB: 1) is transesophageal echocardiography (TEE) necessary in all cases of SAB; and 2) what is the optimal antibiotic therapy for methicillin resistant Staphylococcus aureus (MRSA) bacteremia? A PubMed search from inception through May 2014 was performed to find studies that addressed the role of TEE in SAB. A second search of PubMed, EMBASE, and The Cochrane Library from 1/1/1990 to 5/28/2014 was performed to find studies that addressed antibiotic treatment of MRSA bacteremia. Studies that reported outcomes of systemic antibiotic therapy for MRSA bacteremia were included. All searches were augmented by review of bibliographic references from included studies. The quality of evidence was assessed using the GRADE system by consensus of independent evaluations by at least two authors. In 9 studies with a total of 3513 patients, use of TEE was associated with higher rates of diagnosis of endocarditis (14–25%) when compared with TTE (2–14%). Five studies proposed criteria to identify patients in whom TEE might safely be avoided. Only one high-quality trial of antibiotic therapy for MRSA bacteremia was identified from the 83 studies considered. Most contemporary management strategies for SAB are based upon low quality evidence. TEE is indicated in most patients with SAB. It may be possible to identify a subset of SAB patients for whom TEE can be safely avoided. Vancomycin and daptomycin are the first-line antibiotic choices for MRSA bacteremia. Well-designed studies to address the management of SAB are desperately needed.
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发表时间: 2013-07-01
影响因子: 14.2
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发表时间: 2012-01-01
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发表时间: 2003-01-15
影响因子: 11.8
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DOI: 10.1086/345476
发表时间: 2003-01-01
影响因子: 11.8
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