Reduced resolution transit delay prescan for quantitative continuous arterial spin labeling perfusion imaging.
Reduced resolution transit delay prescan for quantitative continuous arterial spin labeling perfusion imaging.
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DOI：
10.1002/mrm.23103
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发表时间：
2012-05
影响因子：
3.3
通讯作者：
Alsop, David C.
中科院分区：
文献类型：
--
作者：
Dai, Weiying;Robson, Philip M.;Shankaranarayanan, Ajit;Alsop, David C.
当标记和标记血液在组织中标记的血液到达之间的时间延迟时，动脉自旋标记（ASL）灌注MRI可能会遭受伪影和定量误差。在较大的临床人群中，这种运输延迟尤其不确定，在这种临床人群中可能发生降低或侧支流。通过在许多不同时间延迟的ASL信号采集来测量过境延迟通常会延长成像时间并降低所得灌注图像的灵敏度。但是，在与灌注图像相同的空间分辨率上获取过境延迟图可能是不需要的，但是，由于过境延迟地图往往包含很少的高空间分辨率信息。在这里，我们提出使用降低的空间分辨率ASL Prescan来快速测量过境延迟。描述了使用派生的过境延迟信息来优化和量化更高分辨率连续ASL灌注图像的方法。正常志愿者的结果表明，不同大脑区域的运输延迟的异质性，导致量化误差而没有过境图，并证明了这种灌注和过境延迟定量的可行性。
Arterial Spin Labeling (ASL) perfusion MRI can suffer from artifacts and quantification errors when the time delay between labeling and arrival of labeled blood in the tissue is uncertain. This transit delay is particularly uncertain in broad clinical populations, where reduced or collateral flow may occur. Measurement of transit delay by acquisition of the ASL signal at many different time delays typically extends the imaging time and degrades the sensitivity of the resulting perfusion images. Acquisition of transit delay maps at the same spatial resolution as perfusion images may not be necessary, however, because transit delay maps tend to contain little high spatial resolution information. Here, we propose the use of a reduced spatial resolution ASL prescan for the rapid measurement of transit delay. Approaches to using the derived transit delay information to optimize and quantify higher resolution continuous ASL perfusion images are described. Results in normal volunteers demonstrate heterogeneity of transit delay across different brain regions that lead to quantification errors without the transit maps and demonstrate the feasibility of this approach to perfusion and transit delay quantification.
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影响因子：
3.3
作者：
Duhamel, G;de Bazelaire, U;Alsop, DC
通讯作者：
Alsop, DC
影响因子：
3.3
作者：
MacIntosh, Bradley J.;Filippini, Nicola;Jezzard, Peter
通讯作者：
Jezzard, Peter
影响因子：
2.2
作者：
Hwang, TL;van Zijl, PCM;Garwood, M
通讯作者：
Garwood, M
影响因子：
4.4
作者：
Lu, HZ;Nagae-Poetscher, LM;van Zijl, PCM
通讯作者：
van Zijl, PCM
影响因子：
9.9
作者：
Detre, JA;Alsop, DC;Raps, EC
通讯作者：
Raps, EC