Inflammatory Effects of Bothrops Phospholipases A(2): Mechanisms Involved in Biosynthesis of Lipid Mediators and Lipid Accumulation.
Inflammatory Effects of Bothrops Phospholipases A(2): Mechanisms Involved in Biosynthesis of Lipid Mediators and Lipid Accumulation.
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Bothrops磷脂酶A的炎症效应（2）：脂质介质生物合成和脂质积累的机制。
DOI：
10.3390/toxins13120868
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发表时间：
2021-12-04
期刊：
影响因子：
4.2
通讯作者：
Teixeira C
中科院分区：
文献类型：
--
作者：
Moreira V;Leiguez E;Janovits PM;Maia-Marques R;Fernandes CM;Teixeira C
磷脂酶 A2 (PLA2) 是蝰蛇和响尾蛇毒液中存在的主要蛋白质组之一。蛇毒 PLA2 (svPLA2) 表现出显着的功能多样性，因为它们被描述可诱导多种毒性作用。局部炎症是蝰蛇类和响尾蛇类蛇咬伤的一个重要特征，并且已经研究了多种 svPLA2 的促炎特性。此外，根据其分子、结构和功能特性，viperid svPLA2被分类为IIA类分泌型PLA2，其中包括哺乳动物炎症性sPLA2。因此，对 svPLA2s 的研究对于更好地了解此类酶在蛇毒中的作用以及 GIIA sPLA2s 在病理生理状况中的参与以及新治疗剂的开发至关重要。在这篇综述中，我们重点介绍了已经确定了 svPLA2 炎症活性的研究，特别是来自博索普属蛇（拉丁美洲主要的医学上重要的蛇）的炎症活性的研究，并且我们描述了我们对其炎症作用背后机制的集体理解的最新进展。我们还讨论了剖析这些毒液酶在炎症细胞中作用的研究，重点关注参与脂质介质生物合成和免疫活性细胞中脂质积累的分子机制和信号通路。
Phospholipases A2s (PLA2s) constitute one of the major protein groups present in the venoms of viperid and crotalid snakes. Snake venom PLA2s (svPLA2s) exhibit a remarkable functional diversity, as they have been described to induce a myriad of toxic effects. Local inflammation is an important characteristic of snakebite envenomation inflicted by viperid and crotalid species and diverse svPLA2s have been studied for their proinflammatory properties. Moreover, based on their molecular, structural, and functional properties, the viperid svPLA2s are classified into the group IIA secreted PLA2s, which encompasses mammalian inflammatory sPLA2s. Thus, research on svPLA2s has attained paramount importance for better understanding the role of this class of enzymes in snake envenomation and the participation of GIIA sPLA2s in pathophysiological conditions and for the development of new therapeutic agents. In this review, we highlight studies that have identified the inflammatory activities of svPLA2s, in particular, those from Bothrops genus snakes, which are major medically important snakes in Latin America, and we describe recent advances in our collective understanding of the mechanisms underlying their inflammatory effects. We also discuss studies that dissect the action of these venom enzymes in inflammatory cells focusing on molecular mechanisms and signaling pathways involved in the biosynthesis of lipid mediators and lipid accumulation in immunocompetent cells.
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影响因子：
3.7
作者：
Ahmad, Nurul Saadah;Tan, Toh Leong;Yusof, Yasmin Anum Mohd
通讯作者：
Yusof, Yasmin Anum Mohd
影响因子：
64.8
作者：
Belich, MP;Salmerón, A;Ley, SC
通讯作者：
Ley, SC
影响因子：
32.4
作者：
Buckley, Christopher D.;Gilroy, Derek W.;Serhan, Charles N.
通讯作者：
Serhan, Charles N.
影响因子：
6.8
作者：
Aufenanger, J;Samman, M;Bertsch, T
通讯作者：
Bertsch, T
影响因子：
4.8
作者：
Anthonsen, MW;Solhaug, A;Johansen, B
通讯作者：
Johansen, B