Strong gametocytocidal effect of methylene blue-based combination therapy against falciparum malaria: a randomised controlled trial.
Strong gametocytocidal effect of methylene blue-based combination therapy against falciparum malaria: a randomised controlled trial.
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DOI：
10.1371/journal.pone.0005318
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发表时间：
2009
期刊：
影响因子：
3.7
通讯作者：
Müller O
中科院分区：
文献类型：
--
作者：
Coulibaly B;Zoungrana A;Mockenhaupt FP;Schirmer RH;Klose C;Mansmann U;Meissner PE;Müller O
随着新的预防和治疗干预措施的出现，近年来全球疟疾控制工作得到了显著加强。有效减少疟疾配子细胞血症的药物可能有助于在当地消灭疟疾，并可能有助于长期消灭疟疾。我们在这里报告的影响，亚甲蓝（MB）为基础的疟疾联合治疗配子体细胞血症在布基纳法索的随机对照试验。在布基纳法索西北部的努纳对180名6-10岁的无并发症恶性疟疾儿童进行了一项开放标签、随机对照、II期研究。儿童随机接受MB-青蒿琥酯（AS）、MB-阿莫地喹（AQ）和AS-AQ（当地标准治疗）。总体随访时间为28天，配子体血症随访时间为14天。治疗组的基线特征相似，只有1例失访。与AS-AQ相比，两种含MB方案在随访第3、7和14天均与配子体携带率显著降低相关。在基线时有和无恶性疟原虫配子体血症的患者中均观察到这种效应。MB显示出明显的杀配子细胞活性，其似乎对现有和发育中的恶性疟原虫配子细胞都起作用。因此，基于MB的联合疗法有可能减少恶性疟原虫疟疾在流行地区的传播，这对未来的消除和根除战略具有重要意义。ClinicalTrials.gov NCT00354380
With the availability of new preventive and curative interventions, global malaria control has been strengthened significantly in recent years. Drugs effective in reducing malaria gametocytaemia might contribute to local elimination and possible long-term eradication. We here report on the effects of methylene blue (MB)-based malaria combination therapy on gametocytaemia during a randomised-controlled trial in Burkina Faso. An open-label randomised controlled phase II study in 180 children aged 6–10 years with uncomplicated falciparum malaria was conducted in Nouna, north-western Burkina Faso. Children were randomised to MB–artesunate (AS), MB–amodiaquine (AQ), and AS-AQ (local standard of care). Overall follow-up was for 28 days, follow-up for gametocytaemia was for 14 days. The treatment groups were similar in baseline characteristics and there was only one loss to follow-up. Compared to AS-AQ, both MB-containing regimens were associated with significantly reduced gametocyte carrier rates during follow-up days 3, 7, and 14. This effect was seen both in patients with and without P. falciparum gametocytaemia at baseline. MB reveals pronounced gametocytocidal activity which appears to act against both existing and developing P. falciparum gametocytes. MB-based combination therapy thus has the potential to reduce transmission of P. falciparum malaria in endemic regions, which has important implications for future elimination and eradication strategies. ClinicalTrials.gov NCT00354380
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影响因子：
105.7
作者：
Müller, O;Becher, H;Garenne, M
通讯作者：
Garenne, M
影响因子：
3.3
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1.5
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影响因子：
168.9
作者：
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通讯作者：
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影响因子：
168.9
作者：
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通讯作者：
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