Role of LncRNAs in regulating cancer amino acid metabolism.
Role of LncRNAs in regulating cancer amino acid metabolism.
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DOI：
10.1186/s12935-021-01926-8
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发表时间：
2021-04-13
影响因子：
5.8
通讯作者：
Zhang Z
中科院分区：
文献类型：
--
作者：
Guo Y;Lv B;Liu R;Dai Z;Zhang F;Liang Y;Yu B;Zeng D;Lv XB;Zhang Z
肿瘤细胞的代谢变化是一个极其复杂的过程，涉及多种信号通路的交叉和整合。与正常组织相比，癌细胞表现出独特的代谢特征，称为代谢重编程，这被认为是癌症发生的标志。近年来随着对肿瘤研究的深入，人们逐渐发现氨基酸代谢在肿瘤发生发展中起着至关重要的作用。长链非编码RNA（longnoncodingRNA，lncRNA）是最早发现的参与多种重要生物学过程的RNA，在肿瘤组织中表达异常，参与肿瘤发生的广泛调控。本文综述了癌症中氨基酸代谢的重编程以及lncRNA如何通过与其他大分子物质相互作用参与调控网络。了解lncRNA在肿瘤氨基酸重编程中的功能，可能为肿瘤发生机制和肿瘤治疗新方法的开发提供新的视角。
The metabolic change of tumor cells is an extremely complicated process that involves the intersection and integration of various signal pathways. Compared with normal tissues, cancer cells show distinguished metabolic characteristics called metabolic reprogramming, which has been considered as a sign of cancer occurrence. With the deepening of tumor research in recent years, people gradually found that amino acid metabolism played crucial roles in cancer progression. Long non-coding RNAs (lncRNAs), which are implicated in many important biological processes, were firstly discovered dysregulating in cancer tissues and participating in extensive regulation of tumorigenesis. This review focuses on the reprogramming of amino acid metabolism in cancers and how lncRNAs participate in the regulatory network by interacting with other macromolecular substances. Understanding the functions of lncRNA in amino acid reprogramming in tumors might provide a new vision on the mechanisms of tumorigenesis and the development of new approaches for cancer therapy.
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影响因子：
50.3
作者：
Carroll PA;Diolaiti D;McFerrin L;Gu H;Djukovic D;Du J;Cheng PF;Anderson S;Ulrich M;Hurley JB;Raftery D;Ayer DE;Eisenman RN
通讯作者：
Eisenman RN
影响因子：
11.2
作者：
Dang CV
通讯作者：
Dang CV
影响因子：
10.6
作者：
Forman, Henry Jay;Zhang, Hongqiao;Rinna, Alessandra
通讯作者：
Rinna, Alessandra
DOI：
10.1126/science.1262110
发表时间：
2015-05-08
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
GTEx Consortium
通讯作者：
GTEx Consortium
影响因子：
3.4
作者：
An Q;Han C;Zhou Y;Li F;Li D;Zhang X;Yu Z;Duan Z;Kan Q
通讯作者：
Kan Q