Replacing caloric beverages with water or diet beverages for weight loss in adults: main results of the Choose Healthy Options Consciously Everyday (CHOICE) randomized clinical trial.
Replacing caloric beverages with water or diet beverages for weight loss in adults: main results of the Choose Healthy Options Consciously Everyday (CHOICE) randomized clinical trial.
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DOI：
10.3945/ajcn.111.026278
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发表时间：
2012-03
期刊：
影响因子：
--
通讯作者：
Popkin B
中科院分区：
文献类型：
--
作者：
Tate DF;Turner-McGrievy G;Lyons E;Stevens J;Erickson K;Polzien K;Diamond M;Wang X;Popkin B
背景：用无热量饮料替代热量饮料可能是促进适度减肥的简单策略；然而，这一策略的有效性尚不清楚。目的：我们比较了用水或无糖饮料 (DB) 替代热量饮料作为成人和注意力控制 (AC) 6 个月内减肥的方法。设计：超重和肥胖成年人 [n = 318；体重指数（公斤/平方米）：36.3±5.9； 84% 女性；年龄（平均值±标准差）：42±10.7岁； 54% 黑色]用无热量饮料（水或 DB）代替热量饮料（≥200 kcal/d）或进行他们选择的饮食改变（AC）6 个月。结果：在意向治疗分析中，观察到 0 至 6 个月期间体重和腰围显着减轻，收缩压有所改善。 6个月时的平均（±SEM）体重损失，DB组为-2.5±0.45%，水组为-2.03±0.40%，AC组为-1.76±0.35%；组间没有显着差异。 DB 组在 6 个月时体重减轻 5% 的机会高于 AC 组（OR：2.29；95% CI：1.05、5.01；P = 0.04）。与 AC 组相比，水组在 6 个月时空腹血糖显着降低（P = 0.019），并且在 3 个月（P = 0.0017）和 6 个月（P = 0.049）时水合作用得到改善。在综合分析中，被分配饮料替代的参与者实现 5% 体重减轻的可能性是 AC 参与者的 2 倍（OR：2.07；95% CI：1.02, 4.22；P = 0.04）。结论：用无热量饮料替代热量饮料作为减肥策略，平均体重减轻 2% 至 2.5%。该策略可能具有公共卫生意义，并且是一个简单、直接的信息。该试验在 ClinicalTrials.gov 上注册为 NCT01017783。
Background: Replacement of caloric beverages with noncaloric beverages may be a simple strategy for promoting modest weight reduction; however, the effectiveness of this strategy is not known. Objective: We compared the replacement of caloric beverages with water or diet beverages (DBs) as a method of weight loss over 6 mo in adults and attention controls (ACs). Design: Overweight and obese adults [n = 318; BMI (in kg/m2): 36.3 ± 5.9; 84% female; age (mean ± SD): 42 ± 10.7 y; 54% black] substituted noncaloric beverages (water or DBs) for caloric beverages (≥200 kcal/d) or made dietary changes of their choosing (AC) for 6 mo. Results: In an intent-to-treat analysis, a significant reduction in weight and waist circumference and an improvement in systolic blood pressure were observed from 0 to 6 mo. Mean (±SEM) weight losses at 6 mo were −2.5 ± 0.45% in the DB group, −2.03 ± 0.40% in the Water group, and −1.76 ± 0.35% in the AC group; there were no significant differences between groups. The chance of achieving a 5% weight loss at 6 mo was greater in the DB group than in the AC group (OR: 2.29; 95% CI: 1.05, 5.01; P = 0.04). A significant reduction in fasting glucose at 6 mo (P = 0.019) and improved hydration at 3 (P = 0.0017) and 6 (P = 0.049) mo was observed in the Water group relative to the AC group. In a combined analysis, participants assigned to beverage replacement were 2 times as likely to have achieved a 5% weight loss (OR: 2.07; 95% CI: 1.02, 4.22; P = 0.04) than were the AC participants. Conclusions: Replacement of caloric beverages with noncaloric beverages as a weight-loss strategy resulted in average weight losses of 2% to 2.5%. This strategy could have public health significance and is a simple, straightforward message. This trial was registered at clinicaltrials.gov as NCT01017783.
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影响因子：
158.5
作者：
Knowler, WC;Barrett-Connor, E;Nathan, DM
通讯作者：
Nathan, DM
影响因子：
3.5
作者：
Damschroder, Laura J.;Lutes, Lesley D.;Lowery, Julie C.
通讯作者：
Lowery, Julie C.
影响因子：
--
作者：
Flood, Julie E.;Roe, Liane S.;Rolls, Barbara J.
通讯作者：
Rolls, Barbara J.
影响因子：
6.9
作者：
Duffey, Kiyah J.;Popkin, Barry M.
通讯作者：
Popkin, Barry M.
影响因子：
37.8
作者：
Lutsey, Pamela L.;Steffen, Lyn M.;Stevens, June
通讯作者：
Stevens, June