Recurrent SARS-CoV-2 RNA positivity after COVID-19: a systematic review and meta-analysis.
Recurrent SARS-CoV-2 RNA positivity after COVID-19: a systematic review and meta-analysis.
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DOI：
10.1038/s41598-020-77739-y
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发表时间：
2020-11-26
影响因子：
4.6
通讯作者：
Aljunid SM
中科院分区：
文献类型：
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作者：
Azam M;Sulistiana R;Ratnawati M;Fibriana AI;Bahrudin U;Widyaningrum D;Aljunid SM
本研究旨在估计COVID-19恢复后复发SARS-CoV-2 RNA阳性的发生率，并确定与复发阳性相关的因素。我们检索了PubMed、MedRxiv、BioRxiv、科克伦图书馆、ClinicalTrials.gov和世界卫生组织国际临床试验注册处，以查找截至2020年6月12日发表的研究。对研究进行了审查，以确定偏倚风险。使用随机效应模型来汇总结果。使用I2评估杂合性。纳入了2568人的14项研究。复发性SARS-CoV-2阳性的发生率为14.8%（95%置信区间[CI] 11.44-18.19%）。从疾病发作到复发的时间间隔的汇总估计值为35.4天（95% CI 32.65-38.24天），从末次阴性到复发阳性结果的时间间隔为9.8天（95% CI 7.31-12.22天）。年龄较小和初始疾病时间较长的患者更有可能经历复发的SARS-CoV-2阳性，而糖尿病、严重疾病和淋巴细胞计数低的患者则不太可能经历。本研究的结论是，复发性SARS-CoV-2阳性的发生率为14.8%，这表明必须进行进一步的研究，以阐明长期或复发性RNA阳性的感染个体的可能性。
Present study aimed to estimate the incidence of recurrent SARS-CoV-2 RNA positivity after recovery from COVID-19 and to determine the factors associated with recurrent positivity. We searched the PubMed, MedRxiv, BioRxiv, the Cochrane Library, ClinicalTrials.gov, and the World Health Organization International Clinical Trials Registry for studies published to June 12, 2020. Studies were reviewed to determine the risk of bias. A random-effects model was used to pool results. Heterogeneity was assessed using I2. Fourteen studies of 2568 individuals were included. The incidence of recurrent SARS-CoV-2 positivity was 14.8% (95% confidence interval [CI] 11.44–18.19%). The pooled estimate of the interval from disease onset to recurrence was 35.4 days (95% CI 32.65–38.24 days), and from the last negative to the recurrent positive result was 9.8 days (95% CI 7.31–12.22 days). Patients with younger age and a longer initial illness were more likely to experience recurrent SARS-CoV-2 positivity, while patients with diabetes, severe disease, and a low lymphocyte count were less likely to experience. Present study concluded that the incidence of recurrent SARS-CoV-2 positivity was 14.8% suggesting further studies must be conducted to elucidate the possibility of infectious individuals with prolonged or recurrent RNA positivity.
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影响因子：
--
作者：
An J;Liao X;Xiao T;Qian S;Yuan J;Ye H;Qi F;Shen C;Wang L;Liu Y;Cheng X;Li N;Cai Q;Wang F;Chen J;Li G;Cai Q;Liu Y;Wang Y;Zhang F;Fu Y;He Q;Tan X;Liu L;Zhang Z
通讯作者：
Zhang Z
影响因子：
13.6
作者：
Qin, Jing;You, Chong;Zhou, Xiao-Hua
通讯作者：
Zhou, Xiao-Hua
DOI：
10.1073/pnas.1211138109
发表时间：
2012-09-11
影响因子：
11.1
作者：
Lin, Wen-Hsuan W.;Kouyos, Roger D.;Griffin, Diane E.
通讯作者：
Griffin, Diane E.
影响因子：
6.1
作者：
Ling, Yun;Xu, Shui-Bao;Lu, Hong-Zhou
通讯作者：
Lu, Hong-Zhou
影响因子：
12.7
作者：
Kang, Hanyujie;Wang, Yishan;Liu, Xuefeng
通讯作者：
Liu, Xuefeng