Caloric restriction increases ketone bodies metabolism and preserves blood flow in aging brain.
Caloric restriction increases ketone bodies metabolism and preserves blood flow in aging brain.
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DOI：
10.1016/j.neurobiolaging.2015.03.012
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发表时间：
2015-07
影响因子：
4.2
通讯作者：
Watts L
中科院分区：
文献类型：
--
作者：
Lin AL;Zhang W;Gao X;Watts L
卡路里限制(CR)已被证明可以延长多种物种的寿命和健康寿命。然而，CR对活体脑功能的影响还远未被研究。在这项研究中，我们使用多项神经成像方法来表征CR诱导的衰老大鼠脑代谢和血管功能的变化。我们发现，与年龄匹配的和年轻的(5月龄)对照组相比，老年(24月龄)CR饮食的大鼠葡萄糖摄取量和乳酸浓度降低，而酮体水平升高。代谢的改变与血管功能的保存有关：与年龄匹配的对照组相比，老年CR大鼠也保持了脑血流量。在研究线粒体三羧酸循环中的代谢产物时，我们发现老年CR大鼠保存了柠檬酸和α-酮戊二酸。我们认为CR具有神经保护作用；酮体、脑血流量和α-酮戊二酸可能在衰老过程中保护脑生理起重要作用。
Caloric restriction (CR) has been shown to increase the life span and health span of a broad range of species. However, CR effects on in vivo brain functions are far from explored. In this study, we used multimetric neuroimaging methods to characterize the CR-induced changes of brain metabolic and vascular functions in aging rats. We found that old rats (24 months of age) with CR diet had reduced glucose uptake and lactate concentration, but increased ketone bodies level, compared with the age-matched and young (5 months of age) controls. The shifted metabolism was associated with preserved vascular function: old CR rats also had maintained cerebral blood flow relative to the age-matched controls. When investigating the metabolites in mitochondrial tricarboxylic acid cycle, we found that citrate and α-ketoglutarate were preserved in the old CR rats. We suggest that CR is neuroprotective; ketone bodies, cerebral blood flow, and α-ketoglutarate may play important roles in preserving brain physiology in aging.
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影响因子：
29
作者：
Lanza IR;Zabielski P;Klaus KA;Morse DM;Heppelmann CJ;Bergen HR 3rd;Dasari S;Walrand S;Short KR;Johnson ML;Robinson MM;Schimke JM;Jakaitis DR;Asmann YW;Sun Z;Nair KS
通讯作者：
Nair KS
DOI：
10.1126/science.1173635
发表时间：
2009-07-10
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Colman RJ;Anderson RM;Johnson SC;Kastman EK;Kosmatka KJ;Beasley TM;Allison DB;Cruzen C;Simmons HA;Kemnitz JW;Weindruch R
通讯作者：
Weindruch R
影响因子：
1.3
作者：
Lin AL;Rothman DL
通讯作者：
Rothman DL
DOI：
10.1073/pnas.83.4.1140
发表时间：
1986-02-01
影响因子：
11.1
作者：
FOX, PT;RAICHLE, ME
通讯作者：
RAICHLE, ME
DOI：
10.1016/j.bbrc.2011.05.008
发表时间：
2011-06-03
影响因子：
3.1
作者：
Choi, Joon-Seok;Choi, Kyung-Mi;Lee, Cheol-Koo
通讯作者：
Lee, Cheol-Koo