Association of serum uric acid levels with suicide risk in female patients with major depressive disorder: a comparative cross-sectional study.
Association of serum uric acid levels with suicide risk in female patients with major depressive disorder: a comparative cross-sectional study.
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重度抑郁症女性患者血清尿酸水平与自杀风险的关联：一项比较横断面研究。
DOI：
10.1186/s12888-020-02891-8
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发表时间：
2020-09-29
期刊：
影响因子：
4.4
通讯作者：
Su YA
中科院分区：
文献类型：
--
作者：
Chen JX;Feng JH;Zhang LG;Liu Y;Yang FD;Wang SL;Tan YL;Su YA
患有重度抑郁症（MDD）的人自杀风险很高。一些证据表明尿酸（UA）可能参与 MDD 的病理生理学。本研究的目的是评估MDD患者血清UA水平是否与自杀风险相关。本研究纳入了 104 名 MDD 女性患者（52 名有自杀风险的患者和 52 名无自杀风险的患者）和 52 名健康个体。通过小型国际神经精神病学访谈（M.I.N.I.）评估自杀风险。检测空腹血清UA水平以及血糖、血脂和肾功能指标。有自杀风险的MDD患者血清UA水平（245.01±55.44μmol/L）显着低于无自杀风险的MDD患者（274.17±72.65μmol/L）（p=0.017）和健康对照(271.42 ± 55.25 μmol/L) (p = 0.030)。无自杀风险的MDD患者与健康对照之间的血清UA水平没有差异（p = 0.821）。二元logistic回归分析显示MDD患者的自杀风险与血清UA水平降低之间存在显着关系（OR = 0.989，p = 0.010）。血清 UA 水平降低与 MDD 患者的自杀风险相关。嘌呤能系统功能障碍可能与这些患者自杀风险的神经生物学基础有关。
Individuals with major depressive disorder (MDD) have a high suicide risk. Some evidence suggests that uric acid (UA) may be involved in the pathophysiology of MDD. The purpose of this study was to evaluate whether serum UA levels were associated with suicide risk in MDD patients. One hundred four female patients with MDD (52 patients with suicide risk and 52 patients without suicide risk) and 52 healthy individuals were included in this study. The suicide risk was evaluated by Mini International Neuropsychiatric Interview (M.I.N.I.). Fasting serum levels of UA, as well as glucose, lipid and renal function indicators were measured. Serum UA levels in MDD patients with suicide risk (245.01 ± 55.44 μmol/L) were significantly lower than those in MDD patients without suicide risk (274.17 ± 72.65 μmol/L) (p = 0.017) and healthy controls (271.42 ± 55.25 μmol/L) (p = 0.030). There was no difference in serum UA levels between the MDD patients without suicide risk and healthy controls (p = 0.821). Binary logistic regression analysis revealed a significant relationship between suicide risk and decreased serum UA levels (OR = 0.989, p = 0.010) in MDD patients. Decreased serum UA levels were associated with suicide risk in MDD patients. Purinergic system dysfunction may be involved in the neurobiological basis of suicide risk in these patients.
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影响因子：
1.6
作者：
Gu Y;Han B;Wang L;Chang Y;Zhu L;Ren W;Yan M;Zhang X;He J
通讯作者：
He J
影响因子：
6.6
作者：
Bernal, M.;Haro, J. M.;Alonso, J.
通讯作者：
Alonso, J.
影响因子：
5.3
作者：
Jimenez-Fernandez, Sara;Gurpegui, Manuel;Correll, Christoph U.
通讯作者：
Correll, Christoph U.
DOI：
10.1073/pnas.78.11.6858
发表时间：
1981-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
作者：
AMES, BN;CATHCART, R;HOCHSTEIN, P
通讯作者：
HOCHSTEIN, P
影响因子：
11.3
作者：
Bartoli, Francesco;Crocamo, Cristina;Carra, Giuseppe
通讯作者：
Carra, Giuseppe