Reconsolidation blockade for the treatment of addiction: challenges, new targets, and opportunities.
Reconsolidation blockade for the treatment of addiction: challenges, new targets, and opportunities.
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DOI：
10.1101/lm.046771.117
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发表时间：
2018-09
期刊：
影响因子：
--
通讯作者：
Milton AL
中科院分区：
文献类型：
--
作者：
Exton-McGuinness MTJ;Milton AL
成瘾是一种慢性复发性疾病。病理性药物寻求的进展被认为是由适应不良的学习过程驱动的，这些学习过程存储和维持联想记忆，将药物兴奋与环境中的线索和行动联系起来。这些记忆可以对巴甫洛夫关联进行编码，巴甫洛夫关联将预测性刺激（例如，人，地方和用具）与享乐药物高，以及工具学习所需的行动，以获得药物相关的奖励。然而，习得记忆不是永久性的，最近人们对利用重新巩固的过程来消除或显著削弱适应不良的记忆以治疗包括成瘾在内的几种心理健康障碍产生了很大的兴趣。正常情况下，再巩固用于更新和维持记忆的适应性相关性，然而在关键的“再巩固窗口”内施用遗忘剂可以削弱甚至消除适应不良的记忆。在这里，我们讨论了该领域的最新进展，包括正在进行的努力，将临床前再巩固研究的动物模型转化为临床实践。
Addiction is a chronic, relapsing disorder. The progression to pathological drug-seeking is thought to be driven by maladaptive learning processes which store and maintain associative memory, linking drug highs with cues and actions in the environment. These memories can encode Pavlovian associations which link predictive stimuli (e.g., people, places, and paraphernalia) with a hedonic drug high, as well as instrumental learning about the actions required to obtain drug-associated incentives. Learned memories are not permanent however, and much recent interest has been generated in exploiting the process of reconsolidation to erase or significantly weaken maladaptive memories to treat several mental health disorders, including addictions. Normally reconsolidation serves to update and maintain the adaptive relevance of memories, however administration of amnestic agents within the critical “reconsolidation window” can weaken or even erase maladaptive memories. Here we discuss recent advances in the field, including ongoing efforts to translate preclinical reconsolidation research in animal models into clinical practice.
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