ELECTRICAL PROPERTIES OF HYPOTHALAMIC NEUROENDOCRINE CELLS.
ELECTRICAL PROPERTIES OF HYPOTHALAMIC NEUROENDOCRINE CELLS.
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DOI：
10.1085/jgp.47.4.691
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发表时间：
1964-03
期刊：
影响因子：
--
通讯作者：
KANDEL ER
中科院分区：
文献类型：
--
作者：
KANDEL ER
已经通过细胞内记录研究了金鱼下丘脑神经内分泌细胞。细胞显示出 50 mv 的静息电位和高达 117 mv 的动作电位，随后是持久且显着的二相超极化后电位。动作电位分两步发生，表明顺序入侵。 “总”神经元（输入）电阻经测量为 3.3 x 107 Ω，总神经元时间常数为 42 毫秒。由嗅道刺激产生的顺向齐射，产生分级的兴奋性突触后电位。因此，这些神经内分泌细胞似乎具有与其他中枢神经元相似的电膜特性。逆向齐射（垂体刺激）产生抑制性突触后电位，其潜伏期仅比逆向尖峰的潜伏期稍长，表明存在循环性侧支循环。这一发现表明，神经内分泌细胞作为一种神经元，其轴突仅与血管形成接触，而不与其他神经元或效应细胞形成接触，这一概念过于严格。用稀（0.3％）海水灌注鳃会抑制自发活动。这种抑制作用与最近的研究有关，该研究表明金鱼下丘脑激素促进 Na+ 穿过鳃膜流入。
Goldfish hypothalamic neuroendocrine cells have been investigated with intracellular recordings. The cells showed resting potentials of 50 mv and action potentials up to 117 mv followed by a long lasting and prominent diphasic hyperpolarizing afterpotential. The action potential occurred in two steps indicating sequential invasion. "Total" neuron (input) resistance was measured to be 3.3 x 107 Ω and total neuron time constant was 42 msec. Orthodromic volleys, produced by olfactory tract stimulation, generated graded excitatory postsynaptic potentials. These neuroendocrine cells seem, therefore, to have electrical membrane properties that are similar to those of other central neurons. Antidromic volleys (pituitary stimulation) produced inhibitory post-synaptic potentials whose latency was only slightly longer than that of the antidromic spike indicating the presence of recurrent collaterals. This finding suggests that the concept of the neuroendocrine cell as a neuron whose axon forms contacts only on blood vessels and not on other neurons or effector cells is too restrictive. Perfusion of the gills with dilute (0.3 per cent) sea water produced an inhibition of spontaneous activity. This inhibition is discussed in relation to recent work which demonstrates that goldfish hypothalamic hormones facilitate Na+ influx across the gill membrane.
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影响因子：
4.8
作者：
GERSCHENFELD, HM;TRAMEZZANI, JH;DEROBERTIS, E
通讯作者：
DEROBERTIS, E
影响因子：
56.9
作者：
BODIAN, D
通讯作者：
BODIAN, D
影响因子：
2.7
作者：
BENNETT, MVL;FOX, S
通讯作者：
FOX, S
影响因子：
--
作者：
BROOKS, CM;LANGE, G;USHIYAMA, J
通讯作者：
USHIYAMA, J
影响因子：
2.5
作者：
KANDEL, ER;SPENCER, WA;BRINLEY, FJ
通讯作者：
BRINLEY, FJ