Structural and Functional Neural Correlates of Treatment Response for Interpersonal Psychotherapy for Depressed Adolescents.
Structural and Functional Neural Correlates of Treatment Response for Interpersonal Psychotherapy for Depressed Adolescents.
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抑郁症青少年人际心理治疗反应的结构和功能神经相关性
DOI：
10.3390/jcm11071878
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发表时间：
2022-03-28
影响因子：
3.9
通讯作者：
Gunlicks-Stoessel M
中科院分区：
文献类型：
--
作者：
Klimes-Dougan B;Başgöze Z;Mueller B;Wiglesworth A;Carosella KA;Westlund Schreiner M;Bortnova A;Reigstad K;Cullen KR;Gunlicks-Stoessel M
精准医学方法通过提供关于哪些人将从哪些治疗中受益的信息，为推进当前的临床实践带来了巨大的希望。这项初步研究评估了与青少年抑郁症有关的显着性和情绪脑区的基线结构和功能，特别是杏仁核和前扣带皮层（ACC），预测对抑郁青少年人际心理治疗（IPT-A）的反应。被诊断患有抑郁症的青少年（n = 15;平均年龄= 14.5（1.6）; 80.0%为女性）在开始为期16周的IPT-A试验之前完成脑部扫描。在治疗试验之前、期间和之后完成了评估抑郁症状的临床措施。结果表明，在基线时，在情感匹配任务和杏仁核-ACC静息状态功能连接的背景下，更大的ACC激活与抑郁症状的更大改善相关。几乎没有证据表明大脑结构可以预测抑郁症状的变化。本研究是第一个评估IPT-A反应的神经预测因子。虽然结果是初步的，但这些发现为未来的研究提供了一些途径，希望更多的人能从治疗中受益。
Precision medicine approaches hold tremendous promise to advance current clinical practice by providing information about which individuals will benefit from which treatments. This pilot study evaluated if baseline structure and function of the salience and emotion brain regions implicated in adolescent depression, specifically the amygdala and anterior cingulate cortex (ACC), predict response to Interpersonal Psychotherapy for Depressed Adolescents (IPT-A). Adolescents (n = 15; mean age = 14.5 (1.6); 80.0% female) diagnosed with a depressive disorder completed brain scans before the start of a 16 week trial of IPT-A. Clinical measures assessing depressive symptoms were completed before, during, and after a trial of therapy. Results show that at baseline, greater ACC activation in the context of an emotion-matching task and greater amygdala-ACC resting-state functional connectivity was related to greater improvement in depression symptoms. There was minimal evidence that brain structure predicted changes in depressive symptoms. The present study is the first to evaluate neural predictors of IPT-A response. While the results are preliminary, these findings suggest some avenues for future research to pursue in the hopes that more will benefit from treatment.
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影响因子：
1.7
作者：
Costafreda, Sergi G.;Khanna, Akash;Fu, Cynthia H. Y.
通讯作者：
Fu, Cynthia H. Y.
影响因子：
5.7
作者：
Hariri, AR;Tessitore, A;Weinberger, DR
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作者：
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Lim, Kelvin O.
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Johansen-Berg, H.;Gutman, D. A.;Mayberg, H. S.
通讯作者：
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