Abnormal amygdala resting-state functional connectivity in adolescent depression.
Abnormal amygdala resting-state functional connectivity in adolescent depression.
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DOI：
10.1001/jamapsychiatry.2014.1087
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发表时间：
2014-10
期刊：
影响因子：
25.8
通讯作者：
Lim, Kelvin O.
中科院分区：
文献类型：
--
作者：
Cullen, Kathryn R.;Westlund, Melinda K.;Klimes-Dougan, Bonnie;Mueller, Bryon A.;Houri, Alaa;Eberly, Lynn E.;Lim, Kelvin O.
重度抑郁症（MDD）常出现在青春期，可导致持续性疾病、残疾和自杀。青春期大脑发生的成熟变化凸显了在疾病早期这一时间段研究神经生物学机制的重要性。然而，青少年抑郁症的神经机制研究不足。先前的研究表明杏仁核在情绪障碍的情绪处理中起作用，成人抑郁症研究也显示杏仁核 - 额叶连接存在缺陷。静息态功能磁共振成像（rsfMRI）是一种先进的工具，可用于探测神经网络并确定大脑与行为的关系。
利用rsfMRI检测患有和未患有MDD的青少年的杏仁核静息态功能连接（RSFC），并研究杏仁核RSFC如何与广泛的症状维度相关。
横断面rsfMRI研究。
一所学术医疗中心的抑郁症研究项目。
41名12 - 19岁患有MDD的青少年（男女皆有）以及29名无精神疾病诊断的健康青少年（年龄和性别频率匹配）。
采用全脑功能连接方法，我们检测了全脑中每个体素的血氧水平依赖（BOLD）信号的自发波动与杏仁核的相关性。
患有MDD的青少年杏仁核与海马体、海马旁回和脑干之间的正向RSFC较低；这种连接与总体抑郁、烦躁和疲倦呈负相关，与幸福感呈正相关。患者还表现出杏仁核 - 楔前叶的RSFC更强（正向）（与对照组中杏仁核 - 楔前叶的RSFC为负向相反）。
杏仁核 - 海马体/脑干以及杏仁核 - 楔前叶RSFC受损在抑郁症中此前未被强调，可能是青少年MDD所特有的。这些回路对记忆和自我处理的不同方面以及对情绪的生理反应调节都很重要。研究结果表明了情绪和植物性症状的潜在机制，可能是通过休息时自发产生的记忆和内脏信号处理受损，导致患有抑郁症的青少年出现持续性症状。
Major depressive disorder (MDD) frequently emerges during adolescence and can lead to persistent illness, disability and suicide. The maturational changes that take place in the brain during adolescence underscore the importance of examining neurobiological mechanisms during this time period of early illness. However, neural mechanisms of depression in adolescents have been understudied. Prior research has implicated the amygdala in emotion processing in mood disorders, and adult depression studies have suggested amygdala-frontal connectivity deficits. Resting-state functional magnetic resonance imaging (rsfMRI) is an advanced tool that can be used to probe neural networks and identify brain-behavior relationships. To examine amygdala resting-state functional connectivity (RSFC) in adolescents with and without MDD using rsfMRI, and to examine how amygdala RSFC relates to a broad range of symptom dimensions. Cross-sectional rsfMRI study. Depression research program at an academic medical center. 41 girls and boys aged 12–19 years with MDD and 29 healthy adolescents (frequency matched on age and sex) with no psychiatric diagnoses. Using a whole-brain functional connectivity approach, we examined correlation of spontaneous fluctuation of blood-oxygen-level-dependent (BOLD) signal of each voxel in the whole brain with that of the amygdala. Adolescents with MDD showed lower positive RSFC between amygdala and hippocampus, parahippocampus and brain stem; this connectivity was inversely correlated with general depression, dysphoria, and lassitude, and positively correlated with well-being. Patients also showed greater (positive) amygdala-precuneus RSFC (in contrast to negative amygdala-precuneus RSFC in controls.) Impaired amygdala-hippocampal/brainstem and amygdala-precuneus RSFC has not previously been highlighted in depression and may be unique to adolescent MDD. These circuits are important for different aspects of memory and self-processing, and of modulation of physiological responses to emotion. The findings suggest potential mechanisms underlying both mood and vegetative symptomatology, potentially via impaired processing of memories and visceral signals that spontaneously arise during rest, contributing to the persistent symptoms experienced by adolescents with depression.
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DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
影响因子：
5.7
作者：
Dewey, Jeffrey;Hana, George;Russell, Troy;Price, Jared;McCaffrey, Daniel;Harezlak, Jaroslaw;Sem, Ekta;Anyanwu, Joy C.;Guttmann, Charles R.;Navia, Bradford;Cohen, Ronald;Tate, David F.
通讯作者：
Tate, David F.
影响因子：
1.7
作者：
Gaffrey, Michael S.;Luby, Joan L.;Barch, Deanna M.
通讯作者：
Barch, Deanna M.
影响因子：
2.5
作者：
Cunningham, MG;Bhattacharyya, S;Benes, FM
通讯作者：
Benes, FM
DOI：
10.1073/pnas.0409848102
发表时间：
2005-02-15
影响因子：
11.1
作者：
Dolcos, F;LaBar, KS;Cabeza, R
通讯作者：
Cabeza, R