CcpA regulates biofilm formation and competence in Streptococcus gordonii.
CcpA regulates biofilm formation and competence in Streptococcus gordonii.
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DOI：
10.1111/j.2041-1014.2011.00633.x
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发表时间：
2012-04
影响因子：
3.7
通讯作者：
Kreth J
中科院分区：
文献类型：
--
作者：
Zheng L;Chen Z;Itzek A;Herzberg MC;Kreth J
戈登链球菌是口腔生物膜群落的重要成员。作为口腔共生链球菌，戈多氏球菌被认为对促进生物膜稳态有益。CcpA被认为是革兰氏阳性细菌中碳分解代谢物抑制的中央调节剂，也参与毒力基因表达的控制。为了进一步确定CcpA在黄僵菌中作为中心调控因子的作用，研究了CcpA对黄僵菌生物膜形成和自然能力的影响。这些表型特征被认为是口腔链球菌应对环境压力的重要因素。在这里，我们证明了CcpA突变体的生物膜形成能力严重受损，细胞外多糖生产缺陷和能力降低。这些数据表明，CcpA参与了大鼠生物膜形成和能力发展的调控。
Streptococcus gordonii is an important member of the oral biofilm community. As oral commensal streptococci, S. gordonii is considered beneficial in promoting biofilm homeostasis. CcpA is known as central regulator of carbon catabolite repression in Gram-positive bacteria and is also involved in the control of virulence gene expression. To further establish the role of CcpA as central regulator in S. gordonii, the effect of CcpA on biofilm formation and natural competence of S. gordonii was investigated. These phenotypic traits have been suggested to be important to oral streptococci in coping with environmental stress. Here we demonstrate that a CcpA mutant was severely impaired in its biofilm forming ability, showed a defect in extracellular polysaccharide production and reduced competence. The data suggest that CcpA is involved in the regulation of biofilm formation and competence development in S. gordonii.
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影响因子：
3.1
作者：
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通讯作者：
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影响因子：
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3.2
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Dong, YQ;Chen, YYM;Burne, RA
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