Evidence for enhanced neural tracking of the speech envelope underlying age-related speech-in-noise difficulties
Evidence for enhanced neural tracking of the speech envelope underlying age-related speech-in-noise difficulties
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增强对与年龄相关的噪声中语音困难的语音包络的神经跟踪的证据
DOI：
10.1101/489237
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
T. Francart
中科院分区：
文献类型：
--
作者：
Lien Decruy;Jonas Vanthornhout;T. Francart
随着年龄的增长，理解噪音中的语言变得更具挑战性。研究表明，听觉时间和认知缺陷在这些与年龄相关的噪音言语障碍中的作用，超出了周围性听力损失。为了更好地了解这些困难背后的神经机制，我们招募了年轻、中年和老年正常听力（NH）成年人，利用脑电图（EEG）研究了言语理解、认知技能和言语包络神经跟踪之间的相互作用。刺激包括被语音加权噪声掩盖的自然语音或竞争说话者，呈现在几个特定主题的语音理解水平上。结果表明，健康衰老导致语音接收阈值呈二次增长，即语音理解能力下降，其中以竞争说话者最为明显。同样，年龄的增长与包膜跟踪的二次增长有关，老年人的包膜跟踪明显增强。此外，信封追踪能力随着语言理解能力的提高而增强，这在老年人中最为明显。由于认知测试在一定程度上解释了包络追踪的可变性，我们的结果支持了这样的假设，即与年轻人相比，老年人的包络追踪增强是大脑中处理语言的区域被激活的结果。从认知的角度来看，这可能反映了认知资源的低效使用，这在行为研究中经常观察到。有趣的是，年龄对低调制频率的听觉稳态反应有相反的影响，这表明不同的神经机制与年龄的增长有复杂的相互作用。我们测量了整个成年人一生中对言语包络的神经跟踪，发现随着年龄的增长，包络跟踪呈二次增长。使用一种比听觉稳态反应更生态有效的方法，我们发现年轻人、老年人和中年听力正常的成年人在言语理解中表现出了信封追踪的增加。此外，这种关联在老年人中似乎更强。
When we grow older, understanding speech in noise becomes more challenging. Research has demonstrated the role of auditory temporal and cognitive deficits in these age-related speech-in-noise difficulties, beyond peripheral hearing loss. To better understand the neural mechanisms underlying these difficulties, we recruited young, middle-aged and older normal-hearing (NH) adults, and investigated the interplay between speech understanding, cognitive skills and neural tracking of the speech envelope using electroencephalography (EEG). The stimuli consisted of natural speech masked by speech-weighted noise or a competing talker, presented at several subject-specific speech understanding levels. The results show that healthy aging resulted in a quadratic increase in the speech reception threshold, i.e., worse speech understanding, most pronounced for the competing talker. Similarly, advancing age was associated with a quadratic increase in envelope tracking with a pronounced enhancement for older adults. Additionally, envelope tracking was found to increase with speech understanding, and this was most apparent for older adults. Since the cognitive tests partly explained the variability in envelope tracking, our results support the hypothesis that enhanced envelope tracking in older adults are the result of the activation of a larger number of brain regions for processing speech, compared to younger adults. From a cognitive perspective, this could reflect the inefficient use of cognitive resources, often observed in behavioral studies. Interestingly, the opposite effect of age was found for auditory steady state responses at low modulation frequencies, suggesting a complex interplay of different neural mechanisms with advancing age. New & Noteworthy We measured neural tracking of the speech envelope across the adult lifespan and found a quadratic increase in envelope tracking with age. Using a more ecologically valid approach than auditory steady state responses, we found that young, older as well as middle-aged normal-hearing adults showed an increase in envelope tracking with speech understanding. Moreover, this association appeared to be stronger for older adults.
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影响因子：
3.7
作者：
O'Sullivan, James A.;Power, Alan J.;Lalor, Edmund C.
通讯作者：
Lalor, Edmund C.
影响因子：
2.4
作者：
Lin FR;Ferrucci L;Metter EJ;An Y;Zonderman AB;Resnick SM
通讯作者：
Resnick SM
影响因子：
2.5
作者：
A. Presacco;J. Simon;S. Anderson
通讯作者：
A. Presacco;J. Simon;S. Anderson
帮助听力受损的老年人在单人比赛中进行语音识别。
影响因子：
2.1
作者：
Humes,LarryE;Coughlin,Maureen
通讯作者：
Coughlin,Maureen
影响因子：
39
作者：
Lin, Frank R.;Yaffe, Kristine;Xia, Jin;Xue, Qian-Li;Harris, Tamara B.;Purchase-Helzner, Elizabeth;Satterfield, Suzanne;Ayonayon, Hilsa N.;Ferrucci, Luigi;Simonsick, Eleanor M.
通讯作者：
Simonsick, Eleanor M.