Hearing loss and cognition in the Baltimore Longitudinal Study of Aging.
Hearing loss and cognition in the Baltimore Longitudinal Study of Aging.
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DOI：
10.1037/a0024238
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发表时间：
2011-11
期刊：
影响因子：
2.4
通讯作者：
Resnick SM
中科院分区：
文献类型：
--
作者：
Lin FR;Ferrucci L;Metter EJ;An Y;Zonderman AB;Resnick SM
通过标准化神经认知测试组评估听力损失与认知功能之间的关系。我们预先假设，在记忆和执行功能测试中，听力损失越严重，认知测试分数越低。
1990 - 1994年，对巴尔的摩纵向衰老研究（BLSA）中347名年龄≥55岁且无轻度认知障碍或痴呆的参与者进行了横断面队列研究，包括听力测试和认知测试。听力损失是根据听力较好的耳朵在0.5、1、2和4kHz的平均听力阈值来定义的。认知测试包括一个标准化的神经认知测试组，涵盖精神状态、记忆、执行功能、处理速度和语言功能等测试。回归模型用于在调整混杂因素后检验听力损失与认知之间的关联。
听力损失越严重，在精神状态（简易精神状态检查表）、记忆（自由回忆）和执行功能（斯特鲁普混合测验、连线测验B）等测试中的得分越低。这些结果在考虑潜在混杂因素、年龄的非线性影响以及排除重度听力损失个体的分析中是稳健的。与25分贝听力损失相关的认知能力下降相当于6.8岁年龄差异所导致的下降。
听力损失与记忆和执行功能测试得分较低独立相关。需要进一步研究听力损失与认知功能的纵向关联，以证实这些横断面研究结果。
To determine the relationship between hearing loss and cognitive function as assessed with a standardized neurocognitive battery. We hypothesized a priori that greater hearing loss is associated with lower cognitive test scores on tests of memory and executive function. A cross-sectional cohort of 347 participants ≥ 55 years in the BLSA without mild cognitive impairment or dementia had audiometric and cognitive testing performed in 1990–1994. Hearing loss was defined by an average of hearing thresholds at 0.5, 1, 2, and 4 kHz in the better-hearing ear. Cognitive testing consisted of a standardized neurocognitive battery incorporating tests of mental status, memory, executive function, processing speed, and verbal function. Regression models were used to examine the association between hearing loss and cognition while adjusting for confounders. Greater hearing loss was significantly associated with lower scores on measures of mental status (Mini-Mental State Exam), memory (Free Recall), and executive function (Stroop Mixed, Trail Making B). These results were robust to analyses accounting for potential confounders, non-linear effects of age, and exclusion of individuals with severe hearing loss. The reduction in cognitive performance associated with a 25 dB hearing loss was equivalent to the reduction associated with an age difference of 6.8 years. Hearing loss is independently associated with lower scores on tests of memory and executive function. Further research examining the longitudinal association of hearing loss with cognitive functioning is needed to confirm these cross-sectional findings.
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影响因子：
--
作者：
Lin, Frank R.;Metter, E. Jeffrey;O'Brien, Richard J.;Resnick, Susan M.;Zonderman, Alan B.;Ferrucci, Luigi
通讯作者：
Ferrucci, Luigi
影响因子：
7.2
作者：
Gussekloo, J;de Craen, AJM;Westendorp, RGJ
通讯作者：
Westendorp, RGJ
影响因子：
168.9
作者：
Fratiglioni, L;Wang, HX;Winblad, B
通讯作者：
Winblad, B
影响因子：
9.9
作者：
Kawas, C;Gray, S;Zonderman, A
通讯作者：
Zonderman, A
DOI：
10.1682/jrrd.2005.01.0006
发表时间：
2005-07-01
影响因子：
--
作者：
Gordon-Salant, S
通讯作者：
Gordon-Salant, S