Distribution of nitric oxide synthase‐immunoreactive interneurons in the spinal trigeminal nucleus
Distribution of nitric oxide synthase‐immunoreactive interneurons in the spinal trigeminal nucleus
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三叉神经脊核中一氧化氮合酶免疫反应性中间神经元的分布
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发表时间：
1994
期刊：
影响因子：
--
通讯作者：
A. Beitz
中科院分区：
文献类型：
--
作者：
C. Dohrn;M. Mullett;R. H. Price;A. Beitz
三叉神经脊束核参与口面感觉信息的传递。神经信使一氧化氮在三叉神经系统内的分布，以及这种简单的气体与三叉神经丘脑神经元之间的可能关系，都没有被仔细研究过。使用免疫细胞化学（针对一氧化氮合酶）和组织化学（NADPH-黄递酶染色）技术，我们发现，一氧化氮神经元和过程在尾侧核和口核背内侧面比其他三叉神经脊束区更突出。为研究一氧化氮与三叉神经丘脑脊束核神经元和三叉神经间中间神经元的关系，用荧光金逆行标记三叉神经脊束核神经元，并将标记的荧光金分别注入丘脑和极间核与尾侧核交界处。随后用NADPH-黄递酶组织化学处理髓质切片。三叉神经脊束核中心肌黄酶染色的神经元均未发现含有荧光金;然而，在三叉神经丘脑神经元附近发现了一些心肌黄酶染色的突起。在三叉神经脊束核注射后，发现许多黄递酶染色的神经元含有荧光金，特别是在尾侧核中，这表明三叉神经脊束核中含有一氧化氮的神经元是三叉神经间中间神经元。总的来说，这些数据表明，一氧化氮是最突出的位于尾侧核的interneurons和这些interneurons引起的过程，appose三叉神经丘脑神经元，提高的可能性，他们可能会间接影响orofacial伤害性处理水平的三叉神经脊束核通过一氧化氮的生产。© 1994 Wiley利斯公司
The spinal trigeminal nucleus is involved in the transmission of orofacial sensory information. Neither the distribution of the neuromessenger, nitric oxide, within the trigeminal system nor the possible relationship of this simple gas with trigeminothalamic neurons has been carefully studied. Using immunocytochemical (against nitric oxide synthase) and histochemical (NADPH‐diaphorase staining) techniques, we have found that nitric oxide neurons and processes are more prominent in the nucleus caudalis and the dorsomedial aspect of the nucleus oralis than in other spinal trigeminal regions. To study the relationship of nitric oxide to trigeminothalamic neurons and intertrigeminal interneurons of the spinal trigeminal nucleus, spinal trigeminal neurons were retrogradely labeled with fluorogold by thalamic injections or by injections into the junction of the nucleus interpolaris and nucleus caudalis. Medullary sections were subsequently processed with NADPH‐diaphorase histochemistry. None of the diaphorase‐stained neurons in the spinal trigeminal nucleus was found to contain fluorogold; however, some diaphorase‐stained processes were found in close proximity to trigeminothalamic neurons. Following spinal trigeminal nucleus injections, many diaphorasestained neurons were found to contain fluorogold, especially in the nucleus caudalis, suggesting that nitric oxide‐containing neurons in the spinal trigeminal nucleus are intertrigeminal interneurons. Collectively, these data indicate that nitric oxide is most prominent in interneurons located in nucleus caudalis and that these interneurons give rise to processes that appose trigeminothalamic neurons, raising the possibility that they may indirectly influence orofacial nociceptive processing at the level of the spinal trigeminal nucleus via nitric oxide production. © 1994 Wiley‐Liss, Inc.
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