Effect of n-3 long-chain polyunsaturated fatty acids on mild cognitive impairment: a meta-analysis of randomized clinical trials
Effect of n-3 long-chain polyunsaturated fatty acids on mild cognitive impairment: a meta-analysis of randomized clinical trials
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n-3长链多不饱和脂肪酸对轻度认知障碍的影响：随机临床试验的荟萃分析
DOI：
10.1038/s41430-019-0544-4
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发表时间：
2019-12
影响因子：
4.7
通讯作者：
Hongmei Yu
中科院分区：
文献类型：
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作者：
Xiaoling Zhang;Hongjuan Han;Xiaoyan Ge;Long Liu;Tong Wang;Hongmei Yu
N-3长链多不饱和脂肪酸（n-3LC-PUFAs）对轻度认知功能障碍（MCI）患者的认知功能有积极的影响，目前仍存在争议。这项荟萃分析的目的是评估过去10年发表的关于n-3 LC-PUFA摄入对MCI患者影响的科学证据，以探讨n-3 LC-PUFA是否具有积极的有效性。使用Google Scholar、EMBASE和PubMed数据库进行了全面的文献检索。使用随机效应模型计算所有研究的合并效应。合并加权均数差（WMD）和95%可信区间（CI）项，并指示效应。用I2统计法评价杂合度。共有7项随机临床试验，涉及213例干预和221例安慰剂。与安慰剂相比，n-3 LC-PUFAs补充剂能有效改善老年MCI患者的认知功能（WMD = 0.85，95%CI：0.04- 1.67，Z = 2.05，P = 0.04）。在各项研究中检测到轻微异质性。我们的研究结果提供了进一步的证据，n-3 LC-PUFA可能对老年MCI患者有有益的影响。
N-3 long-chain polyunsaturated fatty acids (n-3 LC-PUFAs) have positive effect on cognitive function with mild cognitive impairment (MCI) is still controversial. The aim for this meta-analysis was to assess the scientific evidence published in the last 10 years on the effects of n-3 LC-PUFAs intake on MCI patients to explore whether n-3 LC-PUFAs have positive effective. A comprehensive literature search was developed using the Google Scholar, EMBASE, and PubMed database. The pooled effect for all studies was calculated using random-effects model. And the terms of weighted mean difference (WMD) with 95% confidence interval (CI) was pooled and indicated the effects. Heterogeneity was assessed byI2statistics. A total of seven randomized clinical trials involving 213 cases of intervention and 221 cases of placebo were included in this analysis. Compared with placebo, n-3 LC-PUFAs supplements effectively improved cognition in elders with MCI (WMD = 0.85, 95% CI: 0.04–1.67,Z= 2.05,P= 0.04). Slight heterogeneity was detected across studies. Our results provided further evidence that n-3 LC-PUFAs may have beneficial effect in elderly with MCI.
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营养中的Docosahexaenoic酸信号脂肪组学：衰老，神经炎症，黄斑变性，阿尔茨海默氏症和其他神经退行性疾病的重要性。
影响因子：
8.9
作者：
Bazan NG;Molina MF;Gordon WC
通讯作者：
Gordon WC
影响因子：
3.6
作者：
Rondanelli, Mariangela;Opizzi, Annalisa;Cestaro, Benvenuto
通讯作者：
Cestaro, Benvenuto
DOI：
10.1017/9781108587921.004
发表时间：
2008-11
期刊：
Language in Dementia
影响因子：
--
作者：
Li Qiang
通讯作者：
Li Qiang
影响因子：
6.1
作者：
O. Rangel-Huerta;Á. Gil
通讯作者：
O. Rangel-Huerta;Á. Gil
影响因子：
14
作者：
通讯作者：
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