Ketogenic Diet as a potential treatment for traumatic brain injury in mice.
Ketogenic Diet as a potential treatment for traumatic brain injury in mice.
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DOI：
10.1038/s41598-021-02849-0
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发表时间：
2021-12-07
影响因子：
4.6
通讯作者：
Pick CG
中科院分区：
文献类型：
--
作者：
Har-Even M;Rubovitch V;Ratliff WA;Richmond-Hacham B;Citron BA;Pick CG
创伤性脑损伤（Traumatic brain injury，TBI）是一种脑功能障碍，目前尚无有效的治疗方法.先前的研究表明，在脑损伤后，喂食生酮饮食（KD）的动物比喂食标准饮食（SD）的动物在学习任务中表现更好。本研究的目的是检查KD是否在TBI小鼠模型中具有神经保护作用。我们利用闭合性头部损伤模型在小鼠中诱导TBI，随后进行长达30天的KD/SD。KD后证实血液中酮体水平升高。损伤后评估认知和行为表现，并评估颞叶皮层和海马内的分子和细胞变化。Y-迷宫和新物体识别任务表明，维持在KD上的mTBI小鼠比维持在SD上的mTBI小鼠表现出更好的认知能力。与未受伤组和KD组相比，受伤后维持SD的小鼠显示SIRT 1减少。此外，KD管理减弱了mTBI诱导的星形胶质细胞在齿状回的反应性，并减少了神经元在齿状回和皮质的变性。这些结果支持了越来越多的证据，即KD可能是一种有效的方法，以增加大脑的抗损伤，并提出了一个潜在的新的治疗策略，用于治疗TBI。
Traumatic brain injury (TBI) is a brain dysfunction without present treatment. Previous studies have shown that animals fed ketogenic diet (KD) perform better in learning tasks than those fed standard diet (SD) following brain injury. The goal of this study was to examine whether KD is a neuroprotective in TBI mouse model. We utilized a closed head injury model to induce TBI in mice, followed by up to 30 days of KD/SD. Elevated levels of ketone bodies were confirmed in the blood following KD. Cognitive and behavioral performance was assessed post injury and molecular and cellular changes were assessed within the temporal cortex and hippocampus. Y-maze and Novel Object Recognition tasks indicated that mTBI mice maintained on KD displayed better cognitive abilities than mTBI mice maintained on SD. Mice maintained on SD post-injury demonstrated SIRT1 reduction when compared with uninjured and KD groups. In addition, KD management attenuated mTBI-induced astrocyte reactivity in the dentate gyrus and decreased degeneration of neurons in the dentate gyrus and in the cortex. These results support accumulating evidence that KD may be an effective approach to increase the brain’s resistance to damage and suggest a potential new therapeutic strategy for treating TBI.
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影响因子：
1.9
作者：
Hu, Zhi-Gang;Wang, Han-Dong;Yin, Hong-Xia
通讯作者：
Yin, Hong-Xia
DOI：
10.1523/jneurosci.5657-12.2013
发表时间：
2013-05-22
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Gräff J;Kahn M;Samiei A;Gao J;Ota KT;Rei D;Tsai LH
通讯作者：
Tsai LH
影响因子：
2.7
作者：
Dix, SL;Aggleton, JP
通讯作者：
Aggleton, JP
影响因子：
10.5
作者：
Cohen, Dena E.;Supinski, Andrea M.;Guarente, Leonard P.
通讯作者：
Guarente, Leonard P.
影响因子：
4.7
作者：
Baratz R;Tweedie D;Rubovitch V;Luo W;Yoon JS;Hoffer BJ;Greig NH;Pick CG
通讯作者：
Pick CG