Testosterone, estradiol, DHEA and cortisol in relation to anxiety and depression scores in adolescents.
Testosterone, estradiol, DHEA and cortisol in relation to anxiety and depression scores in adolescents.
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DOI：
10.1016/j.jad.2021.07.026
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发表时间：
2021-11-01
影响因子：
6.6
通讯作者：
Suarez-Lopez JR
中科院分区：
文献类型：
--
作者：
Chronister BN;Gonzalez E;Lopez-Paredes D;Suarez-Torres J;Gahagan S;Martinez D;Barros J;Jacobs DR Jr;Checkoway H;Suarez-Lopez JR
肾上腺激素和性激素失调与抑郁和焦虑的增加独立相关。皮质醇可以调整性激素的产生和荷尔蒙与情绪的联系。这项研究评估性激素和肾上腺激素与抑郁和焦虑的关系和相互作用。我们使用标准化的量表评估了545名厄瓜多尔青少年(11-17岁，50.4%女性，西班牙人)的抑郁和焦虑症状。检测唾液中的睾酮、皮质醇、脱氢表雄酮(DHEA)和雌二醇(仅限男孩)。我们进行了Logistic回归建模，以计算抑郁或焦虑升高(得分≥60)的优势比(OR)，比较激素水平低(<；10%)和激素升高(≥90%)与正常浓度(第10-90%)的参与者。评估皮质醇和睾酮的修饰效果。根据人口统计、人体测量和昼夜节律测量进行调整的模型。在所有参与者中，睾酮升高(OR[95%CI：]=1.78[0.98，3.23])和皮质醇(OR=1.69[0.95，2.99])与焦虑分数升高有轻微关联。在男孩中，雌二醇水平升高与抑郁(OR=4.75[1.95，11.56])和焦虑得分(OR=2.43[1.01，5.84])相关。在线性回归分析中，雌二醇与抑郁(差异/激素增加10%(β=0.45[0.15，0.75])和焦虑评分(β=0.42[0.13，0.72])呈正相关。在男孩中，较高的皮质醇水平加强了抑郁与雌二醇(β=0.5 4[0.12，0.96])、女孩与睾酮(β=−0.19[−0.35，−0.0 3])和脱氢表雄酮(β=−0.12[−0.22，−0.02])的相关性。睾丸素也改变了这种联系。这是一项横断面分析。睾酮、皮质醇和雌二醇(≥第90百分位数)升高与情绪改变有关。皮质醇和睾酮对于大多数荷尔蒙与抑郁和焦虑的关联来说是相当有效的修饰剂。
Adrenal and sex hormone dysregulation have been independently associated with increased depression and anxiety. Cortisol can modify production of sex hormones and hormone-mood associations. This study evaluated associations and interplay of sex and adrenal hormones with depression and anxiety. We assessed 545 Ecuadorian adolescents (11–17y, 50.4% female, ESPINA) for depression and anxiety symptoms using standardized scales. Testosterone, cortisol, dehydroepiandrosterone (DHEA), and estradiol (boys only) were measured in saliva. We performed logistic regression modeling to calculate odds ratios (OR) of elevated depression or anxiety (scores ≥60) comparing participants with low (<10th percentile) and elevated hormones (≥90th percentile) to normal concentrations (10th-90th percentile). Effect modification by cortisol and testosterone was assessed. Models adjusted for demographic, anthropometric, and circadian measures. In all participants, elevated testosterone (OR [95%CI:]=1.78 [0.98, 3.23]) and cortisol (OR=1.69 [0.95, 2.99]) were marginally associated with elevated anxiety scores. In boys, elevated estradiol was associated with elevated depression (OR=4.75 [1.95, 11.56]) and anxiety scores (OR=2.43 [1.01, 5.84]). In linear regression, estradiol was positively associated with depression (difference/10% hormone increase (β=0.45 [0.15, 0.75]) and anxiety scores (β=0.42 [0.13, 0.72]). Higher cortisol levels strengthened the depression association with estradiol in boys (β=0.54 [0.12, 0.96]), and with testosterone (β= −0.19 [−0.35, −0.03]) and DHEA (β= −0.12 [−0.22, −0.02]) in girls. Testosterone also modified associations. This was a cross-sectional analysis. Elevated testosterone, cortisol, and estradiol (≥90th percentile) were associated with altered mood. Cortisol and testosterone were considerable effect modifiers to the associations of most hormones with depression and anxiety.
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影响因子：
5.6
作者：
Isasi, Carmen R.;Carnethon, Mercedes R.;Ayala, Guadalupe X.;Arredondo, Elva;Bangdiwala, Shrikant I.;Daviglus, Martha L.;Delamater, Alan M.;Eckfeldt, John H.;Perreira, Krista;Himes, John H.;Kaplan, Robert C.;Van Horn, Linda
通讯作者：
Van Horn, Linda
循环睾丸激素是运动表现性别差异的激素基础。
影响因子：
20.3
作者：
Handelsman DJ;Hirschberg AL;Bermon S
通讯作者：
Bermon S
影响因子：
2.6
作者：
Olivera-Figueroa LA;Juster RP;Morin-Major JK;Marin MF;Lupien SJ
通讯作者：
Lupien SJ
影响因子：
3.7
作者：
Mouthaan, Joanne;Sijbrandij, Marit;Olff, Miranda
通讯作者：
Olff, Miranda
影响因子：
--
作者：
Kessler, RC;Berglund, P;Walters, EE
通讯作者：
Walters, EE