Incidence of adenocarcinoma of the esophagus among white Americans by sex, stage, and age.

Incidence of adenocarcinoma of the esophagus among white Americans by sex, stage, and age.
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DOI:
10.1093/jnci/djn211
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发表时间:
2008-08-20
期刊:
Journal of the National Cancer Institute
影响因子:
--
通讯作者:
Chow WH
Chow WH
中科院分区:
其他
文献类型:
--
作者:
Brown LM;Devesa SS;Chow WH

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据报道,在白色男性中食管腺癌的发病率迅速增加。我们进一步探讨了白色个体的时间模式,性别,阶段和年龄的监测,流行病学和最终结果程序的数据,22,759例食管癌病例,其中9,526例腺癌,诊断从1975年1月1日至2004年12月31日。在白色男性中,食管癌发病率的增加主要归因于腺癌发病率从1975 - 1979年的1.01/100,000人-年增加到5.69/100人-年,增加了463%,2000 - 2004年的95%置信区间[CI]分别为0.90 - 1.13和5.47 - 5.91。类似的快速增长现在在白色女性中也很明显,在同一时期,其中腺癌发生率从0.17/10万人-年增加到0.74/10万人-年(95%CI分别为0.13 - 0.21和0.67 - 0.81),增加了335%。无论分期和年龄组如何,白色男性和女性的腺癌发病率都有所上升,这表明这些增加是真实的,而不是监测的人为因素。
Rapid increases in the incidence of adenocarcinoma of the esophagus have been reported among white men. We further explore the temporal patterns among white individuals by sex, stage, and age by use of data from the Surveillance, Epidemiology, and End Results program for 22,759 esophageal cancer cases, of which 9,526 cases were adenocarcinoma, diagnosed from January 1, 1975, through December 31, 2004. Among white men, increases in the incidence of esophageal cancer were largely attributed to the 463% increase in the incidence of adenocarcinoma from 1.01 per 100,000 person-years in 1975−1979 to 5.69 per 100,000 person-years in 2000−2004 (95% confidence intervals [CI]=0.90 to 1.13 and 5.47 to 5.91, respectively). A similar rapid increase is now clearly apparent among white women, among whom the adenocarcinoma rate increased 335% from 0.17 to 0.74 per 100,000 person-years (95% CI= 0.13 to 0.21 and 0.67 to 0.81, respectively) over the same time period. Adenocarcinoma rates rose among white men and women regardless of stage and age groups, indicating that these increases are real and not an artifact of surveillance.
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