Is senile dementia of the Alzheimer type associated with hippocampal plasticity?
Is senile dementia of the Alzheimer type associated with hippocampal plasticity?
复制标题
阿尔茨海默型老年痴呆症与海马可塑性有关吗？
DOI：
10.1016/0006-8993(88)90706-8
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发表时间：
1988
期刊：
影响因子：
2.9
通讯作者：
Y. Ben
中科院分区：
文献类型：
--
作者：
A. Represa;C. Duyckaerts;É. Tremblay;J. Hauw;Y. Ben
本文研究了阿尔茨海默型老年性痴呆（SDAT）患者海马中兴奋性氨基酸结合位点的密度。这与年轻和老年非痴呆症病例中发现的情况进行了比较。在SDAT中，谷氨酸盐和红藻氨酸盐结合显著减少。这种减少与神经系统和病理疾病的严重程度呈正相关。尽管广泛的去神经支配的SDAT campi，有没有迹象表明发芽的苔藓纤维，这一观察结果表明，在SDAT患者的海马可塑性的损失。
The density of binding sites for excitatory amino acids in the hippocampus of SDAT (senile dementia of the Alzheimer type) patients has been investigated. This was compared to that found in younger and old non-dement cases. In the SDAT hippocampi there was a significant decrease in the glutamate and kainate binding. This reduction correlated positively with the degree of the severity of neurological and pathological disease. In spite of an extensive denervation of SDAT hippocampi, there was no sign of sprouting of mossy fibers; this observation indicates a loss of plasticity in the hippocampus of SDAT patients.
影响因子：
56.9
作者：
HYMAN, BT;VANHOESEN, GW;BARNES, CL
通讯作者：
BARNES, CL
影响因子：
56.9
作者：
GEDDES, JW;MONAGHAN, DT;CHUI, HC
通讯作者：
CHUI, HC